Mechanistic Characterization of

DNA-Binding Proteins / analysis Enhancer Elements, Genetic / physiology Genetic Predisposition to Disease Guanine Nucleotide Exchange Factors / genetics Heterogeneous-Nuclear Ribonucleoprotein K / physiology Humans Lupus Erythematosus, Systemic / etiology Polymorphism, Single Nucleotide Quantitative Trait Loci
ChIP-qPCR EMSA (electrophoretic mobility shift assay) ERK (extracellular-signal-regulated kinase) RASGRP1 genetic variant homology luciferase

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2019
Historique:
received: 02 11 2018
accepted: 25 04 2019
entrez: 6 6 2019
pubmed: 6 6 2019
medline: 14 8 2020
Statut: epublish

Résumé

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component. We recently identified a novel SLE susceptibility locus near

Identifiants

DOI: 10.3389/fimmu.2019.01066 PMID: 31164884 PMC: PMC6536009
pubmed: 31164884
doi: 10.3389/fimmu.2019.01066
pmc: PMC6536009
doi:

Substances chimiques

DNA-Binding Proteins 0
Guanine Nucleotide Exchange Factors 0
Heterogeneous-Nuclear Ribonucleoprotein K 0
RASGRP1 protein, human 0

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1066

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI132532
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR060366
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD007909
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR073941
Pays : United States

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Auteurs

Julio E Molineros (JE)

Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

Bhupinder Singh (B)

Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

Chikashi Terao (C)

Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Yukinori Okada (Y)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.

Jakub Kaplan (J)

Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

Barbara McDaniel (B)

Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

Shuji Akizuki (S)

Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Celi Sun (C)

Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

Carol F Webb (CF)

Departments of Medicine, Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma, OK, United States.

Loren L Looger (LL)

Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, United States.

Swapan K Nath (SK)

Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Mechanistic Characterization of
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Éléments activateurs (génétique) › Mechanistic Characterization of
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Mechanistic Characterization of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Mechanistic Characterization of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines à motif de reconnaissance de l'ARN › Ribonucléoprotéines nucléaires hétérogènes › Ribonucléoprotéine nucléaire hétérogène K › Mechanistic Characterization of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mechanistic Characterization of
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Lupus érythémateux disséminé › Mechanistic Characterization of
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Mechanistic Characterization of
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Mechanistic Characterization of