JAK Inhibitors Suppress Innate Epigenetic Reprogramming: a Promise for Patients with Sjögren's Syndrome.
Cellular Reprogramming
/ drug effects
DNA Methylation
/ drug effects
Epigenesis, Genetic
/ drug effects
Gene Expression Profiling
Gene Expression Regulation, Enzymologic
Humans
Hydrogen Peroxide
/ metabolism
Immunity, Innate
/ drug effects
Janus Kinase Inhibitors
/ pharmacology
Janus Kinases
/ metabolism
Models, Biological
Phosphorylation
Reactive Oxygen Species
/ metabolism
STAT1 Transcription Factor
/ metabolism
STAT3 Transcription Factor
/ metabolism
Signal Transduction
/ drug effects
Sjogren's Syndrome
/ drug therapy
DNA methylation/hydroxymethylation
DNMTs
Interferon
JAK inhibitors
JAK-STAT pathway
Sjögren’s syndrome
TETs
Journal
Clinical reviews in allergy & immunology
ISSN: 1559-0267
Titre abrégé: Clin Rev Allergy Immunol
Pays: United States
ID NLM: 9504368
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
pubmed:
6
6
2019
medline:
27
10
2020
entrez:
6
6
2019
Statut:
ppublish
Résumé
Pathogenesis of primary Sjögren's syndrome (SjS) remains obscure. However, recent data demonstrate the implication of epigenetic alterations in the DNA methylation/hydroxymethylation process in SjS mostly affecting genes regulated by two innate cytokines, interferon α (IFNα) and IFNγ as well as the oxidative stress pathways. The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is known to be activated by IFN and reactive oxygen species (ROS). This prompts us to test the potential implication of JAK/STAT signaling on DNA methylation/hydroxymethylation alterations in SjS. For this purpose, the human salivary gland (HSG) cell line was used and cells were treated with both types of IFNs and H
Identifiants
pubmed: 31165348
doi: 10.1007/s12016-019-08743-y
pii: 10.1007/s12016-019-08743-y
doi:
Substances chimiques
Janus Kinase Inhibitors
0
Reactive Oxygen Species
0
STAT1 Transcription Factor
0
STAT3 Transcription Factor
0
STAT3 protein, human
0
Hydrogen Peroxide
BBX060AN9V
Janus Kinases
EC 2.7.10.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
182-193Subventions
Organisme : Russian Science Foundation
ID : 17-15-01099
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