Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis.
Adaptor Proteins, Signal Transducing
/ genetics
Animals
Calcium-Binding Proteins
/ genetics
Cell Adhesion Molecules
/ genetics
Cell Lineage
Female
Hematopoietic Stem Cells
/ cytology
Junctional Adhesion Molecule B
/ genetics
Lymphopoiesis
/ genetics
Male
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Receptor, Notch3
/ genetics
Receptors, Cell Surface
/ genetics
Recombinant Proteins
T-Lymphocytes
/ cytology
Jam2
Notch signal
T cell
hematopoietic stem cell
junctional adhesion molecule
stem cell heterogeneity
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
04 06 2019
04 06 2019
Historique:
received:
09
10
2018
revised:
18
03
2019
accepted:
06
05
2019
entrez:
6
6
2019
pubmed:
6
6
2019
medline:
6
8
2020
Statut:
ppublish
Résumé
The distinct lineage potential is a key feature of hematopoietic stem cell (HSC) heterogeneity, but a subset of HSCs specialized for a single lymphoid compartment has not been identified. Here we report that HSCs expressing junctional adhesion molecule 2 (Jam2) at a higher level (Jam2
Identifiants
pubmed: 31167130
pii: S2211-1247(19)30639-4
doi: 10.1016/j.celrep.2019.05.028
pii:
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Calcium-Binding Proteins
0
Cell Adhesion Molecules
0
DLL4 protein, mouse
0
F11R protein, human
0
Junctional Adhesion Molecule B
0
Notch3 protein, mouse
0
Receptor, Notch3
0
Receptors, Cell Surface
0
Recombinant Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2826-2836.e5Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.