Apathy and Disinhibition Related to Neuropathology in Amnestic Versus Behavioral Dementias.
Alzheimer’s disease
apathy
apolipoprotein E4
disinhibition
frontotemporal dementia
frontotemporal lobar degeneration
neuropsychiatric symptoms
Journal
American journal of Alzheimer's disease and other dementias
ISSN: 1938-2731
Titre abrégé: Am J Alzheimers Dis Other Demen
Pays: United States
ID NLM: 101082834
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
pubmed:
7
6
2019
medline:
10
7
2020
entrez:
8
6
2019
Statut:
ppublish
Résumé
Investigating the frequency of apathy and disinhibition in patients clinically diagnosed with dementia of the Alzheimer type (DAT) or behavioral variant frontotemporal dementia (bvFTD) with neuropathology of either Alzheimer disease (AD) or frontotemporal lobar degeneration (FTLD). Retrospective data from 887 cases were analyzed, and the frequencies of apathy and disinhibition were compared at baseline and longitudinally in 4 groups: DAT/AD, DAT/FTLD, bvFTD/FTLD, and bvFTD/AD. Apathy alone was more common in AD (33%) than FTLD (25%), and the combination of apathy and disinhibition was more common in FTLD (43%) than AD (14%; Alzheimer disease neuropathology had the closest association with the neuropsychiatric symptom of apathy, while FTLD was most associated with the combination of apathy and disinhibition. Over time, the frequency of those with apathy increased in both AD and FTLD neuropathology.
Identifiants
pubmed: 31170813
doi: 10.1177/1533317519853466
pmc: PMC7256964
mid: NIHMS1590205
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
337-343Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC008552
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG016976
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075075
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG010483
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG045571
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045571
Pays : United States
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