Progenitor mast cells and tryptase in Q fever.
Coxiella burnetii
Flow cytometry
Mast cells progenitors
Q fever
Tryptase
Journal
Comparative immunology, microbiology and infectious diseases
ISSN: 1878-1667
Titre abrégé: Comp Immunol Microbiol Infect Dis
Pays: England
ID NLM: 7808924
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
15
02
2018
revised:
05
03
2019
accepted:
14
03
2019
entrez:
9
6
2019
pubmed:
9
6
2019
medline:
9
11
2019
Statut:
ppublish
Résumé
Q fever is an infectious disease due to Coxiella burnetii. Following a primary-infection, C. burnetii may persist in some patients, leading to endocarditis and vascular infections. Mast cells (MCs), known for their role in allergic diseases, innate immunity and cardiac function, are produced by bone marrow, circulate as progenitors in the bloodstream and reach tissues for their maturation and activation. The latter may be estimated by measuring serum tryptase levels. We wondered if MC progenitors and tryptase were affected in Q fever. We showed a decrease in MC progenitor count in Q fever patients whereas serum tryptase levels were increased. Taken together, our results show alterations of MC numbers and activity in Q fever patients, suggesting that MC are involved in Q fever pathophysiology.
Identifiants
pubmed: 31174692
pii: S0147-9571(19)30056-6
doi: 10.1016/j.cimid.2019.03.011
pii:
doi:
Substances chimiques
Tryptases
EC 3.4.21.59
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
159-162Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.