An

Animals Cell Line, Tumor Disease Models, Animal Gene Expression Humans Leukemia, Myeloid, Acute / genetics Mice Oncogene Proteins / metabolism Survival Analysis Transcriptional Regulator ERG / metabolism Transfection Transplantation, Heterologous / methods

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
01 08 2019
Historique:
received: 18 10 2018
revised: 21 03 2019
accepted: 04 06 2019
pubmed: 9 6 2019
medline: 16 4 2020
entrez: 9 6 2019
Statut: ppublish

Résumé

Acute leukemia is a rapidly progressing blood cancer with low survival rates. Unfavorable prognosis is attributed to insufficiently characterized subpopulations of leukemia stem cells (LSC) that drive chemoresistance and leukemia relapse. Here we utilized a genetic reporter that assesses stemness to enrich and functionally characterize LSCs. We observed heterogeneous activity of the

Identifiants

DOI: 10.1158/0008-5472.CAN-18-3215 PMID: 31175119
pubmed: 31175119
pii: 0008-5472.CAN-18-3215
doi: 10.1158/0008-5472.CAN-18-3215
doi:

Substances chimiques

ERG protein, mouse 0
Oncogene Proteins 0
Transcriptional Regulator ERG 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3862-3876

Informations de copyright

©2019 American Association for Cancer Research.

Auteurs

Nasma Aqaqe (N)

Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Muhammad Yassin (M)

Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Abed Alkader Yassin (AA)

Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Nour Ershaid (N)

Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Chen Katz-Even (C)

Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Adi Zipin-Roitman (A)

Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Eitan Kugler (E)

Department of Pediatric Hemato-Oncology, Schneider Children Medical Center Petah-Tikva, Israel.
The Gene Development and Environment Pediatric Research Institute, Pediatric Hemato-Oncology, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
Department of Molecular Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Eric R Lechman (ER)

Princess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Olga I Gan (OI)

Princess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Amanda Mitchell (A)

Princess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

John E Dick (JE)

Princess Margaret Cancer Centre, University Health Network and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0002-9527-8317

Shai Izraeli (S)

Department of Pediatric Hemato-Oncology, Schneider Children Medical Center Petah-Tikva, Israel.
The Gene Development and Environment Pediatric Research Institute, Pediatric Hemato-Oncology, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
Department of Molecular Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Michael Milyavsky (M)

Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. mmilyavsky@post.tau.ac.il.
ORCID: 0000-0002-5083-0809

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › An
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › An
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › An
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › An
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › An
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › An
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › An
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › An
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › An
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Régulateur transcriptionnel ERG › An
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Transfection › An
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation hétérologue › An