Eric R Lechman

Affiliations

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

Publications (8)

Nicotinamide phosphoribosyltransferase inhibitors selectively induce apoptosis of AML stem cells by disrupting lipid homeostasis.

Cell stem cell

Avec: Amit Subedi , Qiang Liu , Dhanoop M Ayyathan , David Sharon , Severine Cathelin , Mohsen Hosseini , Changjiang Xu , Veronique Voisin , Gary D Bader , Angelo D'Alessandro , Eric R Lechman , John E Dick , Mark D Minden , Jean C Y Wang , Steven M Chan

Mapping the cellular origin and early evolution of leukemia in Down syndrome.

Science (New York, N.Y.)

Avec: Elvin Wagenblast , Joana Araújo , Olga I Gan , Sarah K Cutting , Alex Murison , Gabriela Krivdova , Maria Azkanaz , Jessica L McLeod , Sabrina A Smith , Blaise A Gratton , Sajid A Marhon , Martino Gabra , Jessie J F Medeiros , Sanaz Manteghi , Jian Chen , Michelle Chan-Seng-Yue , Laura Garcia-Prat , Leonardo Salmena , Daniel D De Carvalho , Sagi Abelson , Mohamed Abdelhaleem , Karen Chong , Maian Roifman , Patrick Shannon , Jean C Y Wang , Johann K Hitzler , David Chitayat , John E Dick , Eric R Lechman

Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML.

Cell reports

Avec: Gabriela Krivdova , Veronique Voisin , Erwin M Schoof , Sajid A Marhon , Alex Murison , Jessica L McLeod , Martino M Gabra , Andy G X Zeng , Stefan Aigner , Brian A Yee , Alexander A Shishkin , Eric L Van Nostrand , Karin G Hermans , Aaron C Trotman-Grant , Nathan Mbong , James A Kennedy , Olga I Gan , Elvin Wagenblast , Daniel D De Carvalho , Leonardo Salmena , Mark D Minden , Gary D Bader , Gene W Yeo , John E Dick , Eric R Lechman

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition.

Leukemia

Avec: Liberalis Debraj Boila , Subhadeep Ghosh , Subham K Bandyopadhyay , Liqing Jin , Alex Murison , Andy G X Zeng , Wasim Shaikh , Satyaki Bhowmik , Siva Sai Naga Anurag Muddineni , Mayukh Biswas , Sayantani Sinha , Shankha Subhra Chatterjee , Nathan Mbong , Olga I Gan , Anwesha Bose , Sayan Chakraborty , Andrea Arruda , James A Kennedy , Amanda Mitchell , Eric R Lechman , Debasis Banerjee , Michael Milyavsky , Mark D Minden , John E Dick , Amitava Sengupta

An

Cancer research

Avec: Nasma Aqaqe , Muhammad Yassin , Abed Alkader Yassin , Nour Ershaid , Chen Katz-Even , Adi Zipin-Roitman , Eitan Kugler , Eric R Lechman , Olga I Gan , Amanda Mitchell , John E Dick , Shai Izraeli , Michael Milyavsky

Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells.

Nature communications

Avec: Elvin Wagenblast , Maria Azkanaz , Sabrina A Smith , Lorien Shakib , Jessica L McLeod , Gabriela Krivdova , Joana Araújo , Leonard D Shultz , Olga I Gan , John E Dick , Eric R Lechman

A novel method for detecting the cellular stemness state in normal and leukemic human hematopoietic cells can predict disease outcome and drug sensitivity.

Leukemia

Avec: Muhammad Yassin , Nasma Aqaqe , Abed Alkader Yassin , Peter van Galen , Eitan Kugler , Bradley E Bernstein , Maya Koren-Michowitz , Jonathan Canaani , Arnon Nagler , Eric R Lechman , John E Dick , Erno Wienholds , Shai Izraeli , Michael Milyavsky

A stemness screen reveals

Blood

Avec: Kerstin B Kaufmann , Laura Garcia-Prat , Qiang Liu , Stanley W K Ng , Shin-Ichiro Takayanagi , Amanda Mitchell , Erno Wienholds , Peter van Galen , Christian A Cumbaa , Mike J Tsay , Chiara Pastrello , Elvin Wagenblast , Gabriela Krivdova , Mark D Minden , Eric R Lechman , Sasan Zandi , Igor Jurisica , Jean C Y Wang , Stephanie Z Xie , John E Dick

Réseau de co-auteurs

John E Dick 8 collaborations

Olga I Gan 5 collaborations

Mark D Minden 4 collaborations

Elvin Wagenblast 4 collaborations

Gabriela Krivdova 4 collaborations

Jean C Y Wang 3 collaborations

Alex Murison 3 collaborations

Jessica L McLeod 3 collaborations

Amanda Mitchell 3 collaborations

Michael Milyavsky 3 collaborations

Qiang Liu 2 collaborations

Veronique Voisin 2 collaborations

Gary D Bader 2 collaborations

Joana Araújo 2 collaborations

Maria Azkanaz 2 collaborations

Sabrina A Smith 2 collaborations

Sajid A Marhon 2 collaborations

Laura Garcia-Prat 2 collaborations

Leonardo Salmena 2 collaborations

Daniel D De Carvalho 2 collaborations

Andy G X Zeng 2 collaborations

Nathan Mbong 2 collaborations

James A Kennedy 2 collaborations

Nasma Aqaqe 2 collaborations

Muhammad Yassin 2 collaborations

Abed Alkader Yassin 2 collaborations

Eitan Kugler 2 collaborations

Shai Izraeli 2 collaborations

Peter van Galen 2 collaborations

Erno Wienholds 2 collaborations

Amit Subedi 1 collaboration

Dhanoop M Ayyathan 1 collaboration

David Sharon 1 collaboration

Severine Cathelin 1 collaboration

Mohsen Hosseini 1 collaboration

Changjiang Xu 1 collaboration

Angelo D'Alessandro 1 collaboration

Steven M Chan 1 collaboration

Sarah K Cutting 1 collaboration

Blaise A Gratton 1 collaboration

Martino Gabra 1 collaboration

Jessie J F Medeiros 1 collaboration

Sanaz Manteghi 1 collaboration

Jian Chen 1 collaboration

Michelle Chan-Seng-Yue 1 collaboration

Sagi Abelson 1 collaboration

Mohamed Abdelhaleem 1 collaboration

Karen Chong 1 collaboration

Maian Roifman 1 collaboration

Patrick Shannon 1 collaboration

Johann K Hitzler 1 collaboration

David Chitayat 1 collaboration

Erwin M Schoof 1 collaboration

Martino M Gabra 1 collaboration

Stefan Aigner 1 collaboration

Brian A Yee 1 collaboration

Alexander A Shishkin 1 collaboration

Eric L Van Nostrand 1 collaboration

Karin G Hermans 1 collaboration

Aaron C Trotman-Grant 1 collaboration

Gene W Yeo 1 collaboration

Liberalis Debraj Boila 1 collaboration

Subhadeep Ghosh 1 collaboration

Subham K Bandyopadhyay 1 collaboration

Liqing Jin 1 collaboration

Wasim Shaikh 1 collaboration

Satyaki Bhowmik 1 collaboration

Siva Sai Naga Anurag Muddineni 1 collaboration

Mayukh Biswas 1 collaboration

Sayantani Sinha 1 collaboration

Shankha Subhra Chatterjee 1 collaboration

Anwesha Bose 1 collaboration

Sayan Chakraborty 1 collaboration

Andrea Arruda 1 collaboration

Debasis Banerjee 1 collaboration

Amitava Sengupta 1 collaboration

Nour Ershaid 1 collaboration

Chen Katz-Even 1 collaboration

Adi Zipin-Roitman 1 collaboration

Lorien Shakib 1 collaboration

Leonard D Shultz 1 collaboration

Bradley E Bernstein 1 collaboration

Maya Koren-Michowitz 1 collaboration

Jonathan Canaani 1 collaboration

Arnon Nagler 1 collaboration

Kerstin B Kaufmann 1 collaboration

Stanley W K Ng 1 collaboration

Shin-Ichiro Takayanagi 1 collaboration

Christian A Cumbaa 1 collaboration

Mike J Tsay 1 collaboration

Chiara Pastrello 1 collaboration

Sasan Zandi 1 collaboration

Igor Jurisica 1 collaboration

Stephanie Z Xie 1 collaboration