Mapping the cellular origin and early evolution of leukemia in Down syndrome.

Animals Antigens, CD34 / analysis Cell Cycle Proteins / genetics Cell Lineage Cell Proliferation Cell Transformation, Neoplastic Chromosomal Proteins, Non-Histone / genetics Chromosomes, Human, Pair 21 / genetics Disease Models, Animal Disease Progression Down Syndrome / complications Female GATA1 Transcription Factor / genetics Hematopoiesis Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells / physiology Heterografts Humans Leukemia, Myeloid / genetics Liver / embryology Male Megakaryocytes / physiology Mice MicroRNAs / genetics Mutation Preleukemia / genetics Protein Kinase Inhibitors / pharmacology Proto-Oncogene Mas Proto-Oncogene Proteins c-kit / analysis Cohesins

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
09 07 2021
Historique:
received: 07 11 2020
revised: 09 03 2021
accepted: 21 05 2021
entrez: 10 7 2021
pubmed: 11 7 2021
medline: 23 7 2021
Statut: ppublish

Résumé

Children with Down syndrome have a 150-fold increased risk of developing myeloid leukemia, but the mechanism of predisposition is unclear. Because Down syndrome leukemogenesis initiates during fetal development, we characterized the cellular and developmental context of preleukemic initiation and leukemic progression using gene editing in human disomic and trisomic fetal hematopoietic cells and xenotransplantation. GATA binding protein 1 (

Identifiants

DOI: 10.1126/science.abf6202 PMID: 34244384
pubmed: 34244384
pii: 373/6551/eabf6202
doi: 10.1126/science.abf6202
pii:
doi:

Substances chimiques

Antigens, CD34 0
Cell Cycle Proteins 0
Chromosomal Proteins, Non-Histone 0
GATA1 Transcription Factor 0
GATA1 protein, human 0
MAS1 protein, human 0
MicroRNAs 0
Protein Kinase Inhibitors 0
Proto-Oncogene Mas 0
STAG2 protein, human 0
KIT protein, human EC 2.7.10.1
Proto-Oncogene Proteins c-kit EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Elvin Wagenblast (E)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada. elvin.wagenblast@uhnresearch.ca john.dick@uhnresearch.ca eric.lechman@uhnresearch.ca.
ORCID: 0000-0002-0709-2759

Joana Araújo (J)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Department of Hematology, Centro Hospitalar Universitário de São João, Porto, 4200-319, Portugal.
Faculty of Medicine, University of Porto, Porto, 4200-319, Portugal.
Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, 4200-135, Portugal.
Instituto Nacional de Investigação Biomédica, University of Porto, Porto, 4200-135, Portugal.

Olga I Gan (OI)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

Sarah K Cutting (SK)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

Alex Murison (A)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

Gabriela Krivdova (G)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Maria Azkanaz (M)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

Jessica L McLeod (JL)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

Sabrina A Smith (SA)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Blaise A Gratton (BA)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
ORCID: 0000-0002-3424-2433

Sajid A Marhon (SA)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
ORCID: 0000-0002-1046-9852

Martino Gabra (M)

Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
ORCID: 0000-0002-5015-4409

Jessie J F Medeiros (JJF)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.
ORCID: 0000-0001-6597-4613

Sanaz Manteghi (S)

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada.
ORCID: 0000-0002-3997-6022

Jian Chen (J)

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada.

Michelle Chan-Seng-Yue (M)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.
ORCID: 0000-0003-3773-9354

Laura Garcia-Prat (L)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
ORCID: 0000-0002-3786-4852

Leonardo Salmena (L)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
ORCID: 0000-0003-4023-658X

Daniel D De Carvalho (DD)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1A8, Canada.
ORCID: 0000-0002-8572-5259

Sagi Abelson (S)

Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.
ORCID: 0000-0003-1747-3819

Mohamed Abdelhaleem (M)

Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
ORCID: 0000-0001-6595-6351

Karen Chong (K)

The Prenatal Diagnosis and Medical Genetics Program, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, ON M5S 1A8, Canada.
Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON M5S 1A8, Canada.

Maian Roifman (M)

The Prenatal Diagnosis and Medical Genetics Program, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, ON M5S 1A8, Canada.
Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON M5S 1A8, Canada.

Patrick Shannon (P)

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON M5S 1A8, Canada.

Jean C Y Wang (JCY)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Division of Medical Oncology and Hematology, University Health Network, Toronto, Ontario M5G 2M9, Canada.
ORCID: 0000-0001-7543-3917

Johann K Hitzler (JK)

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children Research Institute, Toronto, ON M5G 1X8, Canada.
Department of Pediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada.
Division of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
ORCID: 0000-0003-1158-186X

David Chitayat (D)

The Prenatal Diagnosis and Medical Genetics Program, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, ON M5S 1A8, Canada.
Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON M5S 1A8, Canada.

John E Dick (JE)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada. elvin.wagenblast@uhnresearch.ca john.dick@uhnresearch.ca eric.lechman@uhnresearch.ca.
Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
ORCID: 0000-0002-9527-8317

Eric R Lechman (ER)

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada. elvin.wagenblast@uhnresearch.ca john.dick@uhnresearch.ca eric.lechman@uhnresearch.ca.
ORCID: 0000-0001-8874-2874

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mapping the cellular origin and early...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › Antigènes CD34 › Mapping the cellular origin and early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Mapping the cellular origin and early...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › Mapping the cellular origin and early...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Mapping the cellular origin and early...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › Mapping the cellular origin and early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › Mapping the cellular origin and early...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes de mammifère › Chromosomes humains › Chromosomes humains 21-22 et Y › Chromosomes humains de la paire 21 › Mapping the cellular origin and early...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Mapping the cellular origin and early...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Mapping the cellular origin and early...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Maladies chromosomiques › Syndrome de Down › Mapping the cellular origin and early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription GATA › Facteur de transcription GATA-1 › Mapping the cellular origin and early...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Mapping the cellular origin and early...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Mapping the cellular origin and early...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Mapping the cellular origin and early...
questionsmedicales.fr › Régions du corps › Transplants › Hétérogreffes › Mapping the cellular origin and early...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mapping the cellular origin and early...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Mapping the cellular origin and early...
questionsmedicales.fr › Système digestif › Foie › Mapping the cellular origin and early...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Mégacaryocytes › Mapping the cellular origin and early...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mapping the cellular origin and early...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Mapping the cellular origin and early...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mapping the cellular origin and early...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Préleucémie › Mapping the cellular origin and early...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Mapping the cellular origin and early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Proto-oncogène Mas › Mapping the cellular origin and early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-kit › Mapping the cellular origin and early...