Nucleolus: A Central Hub for Nuclear Functions.
3D genome organization
DNA repair and recombination
nuclear compartmentalization
nucleolus
transcription
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
17
12
2018
revised:
24
04
2019
accepted:
26
04
2019
pubmed:
10
6
2019
medline:
16
7
2020
entrez:
10
6
2019
Statut:
ppublish
Résumé
The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is far from being comprehensively understood. Much work on the nucleolus has focused on its role in regulating RNA polymerase I (RNA Pol I) transcription and ribosome biogenesis; however, emerging evidence points to the nucleolus as an organizing hub for many nuclear functions, accomplished via the shuttling of proteins and nucleic acids between the nucleolus and nucleoplasm. Here, we discuss the cellular mechanisms affected by shuttling of nucleolar components, including the 3D organization of the genome, stress response, DNA repair and recombination, transcription regulation, telomere maintenance, and other essential cellular functions.
Identifiants
pubmed: 31176528
pii: S0962-8924(19)30078-9
doi: 10.1016/j.tcb.2019.04.003
pii:
doi:
Substances chimiques
RNA Polymerase I
EC 2.7.7.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
647-659Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.