Multidrug resistance-associated protein 4 in pharmacology: Overview of its contribution to pharmacokinetics, pharmacodynamics and pharmacogenetics.
Anti-infectious and anti-cancer drugs
Drug-drug interactions
Multidrug resistance-associated protein 4
Pharmacogenetics
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
15 Aug 2019
15 Aug 2019
Historique:
received:
05
04
2019
revised:
04
06
2019
accepted:
05
06
2019
pubmed:
10
6
2019
medline:
21
9
2019
entrez:
10
6
2019
Statut:
ppublish
Résumé
MRP4 is an ABC membrane transporter involved in clinical outcomes as it is located in many tissues that manages the transport and the elimination of many drugs. This review explores the implication of MRP4 in clinical pharmacology and the importance of its genetic variability. Although there is no specific recommendation regarding the study of MRP4 in drug development, it should be considered when drugs are eliminated by the kidney or liver or when drug-drug interactions are expected.
Identifiants
pubmed: 31176778
pii: S0024-3205(19)30460-6
doi: 10.1016/j.lfs.2019.06.015
pii:
doi:
Substances chimiques
ABCC4 protein, human
0
Antineoplastic Agents
0
Antiviral Agents
0
Multidrug Resistance-Associated Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
116540Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.