Identification of adenylate kinase 5 antibodies during routine diagnostics in a tissue-based assay: Three new cases and a review of the literature.
Adenylate kinase 5 antibodies
Cell-based assay
Depression
Immunotherapy
Limbic encephalitis
Memory problems
Outcome
Tissue-based assay
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 09 2019
15 09 2019
Historique:
received:
17
04
2019
revised:
27
05
2019
accepted:
28
05
2019
pubmed:
10
6
2019
medline:
12
6
2020
entrez:
10
6
2019
Statut:
ppublish
Résumé
Antibodies against adenylate kinase 5 (AK5) have been described in patients with non-paraneoplastic limbic encephalitis, mainly in men around 70 years of age. Routine testing with specific cell-based assays is not yet available. Three patients with episodic anterograde memory problems and depression had extensive limbic lesions and developed severe atrophy, mainly of the medial temporal lobes. The antibodies were identified in serum and CSF based on the typical staining pattern of AK5 antibodies on a tissue-based assay (here, unfixed mouse brain). Subsequently, they were confirmed by a research laboratory through a cell-based assay.
Identifiants
pubmed: 31177032
pii: S0165-5728(19)30197-3
doi: 10.1016/j.jneuroim.2019.576975
pii:
doi:
Substances chimiques
Autoantibodies
0
Biomarkers
0
Adenylate Kinase
EC 2.7.4.3
adenylate kinase 5
EC 2.7.4.3
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
576975Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.