Improvement of Asparagine Ethylenediamines as Anti-malarial

Antimalarials / chemistry Asparagine / chemistry Drug Resistance / drug effects Ethylenediamines / chemistry Humans Malaria, Falciparum / metabolism Mutation Plasmodium falciparum / drug effects Proteasome Endopeptidase Complex / genetics Proteasome Inhibitors / pharmacology

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
11 07 2019
Historique:
pubmed: 11 6 2019
medline: 2 6 2020
entrez: 11 6 2019
Statut: ppublish

Résumé

The

Identifiants

DOI: 10.1021/acs.jmedchem.9b00363 PMID: 31177777 PMC: PMC7104388
pubmed: 31177777
doi: 10.1021/acs.jmedchem.9b00363
pmc: PMC7104388
mid: NIHMS1577636
doi:

Substances chimiques

Antimalarials 0
Ethylenediamines 0
Proteasome Inhibitors 0
Asparagine 7006-34-0
Proteasome Endopeptidase Complex EC 3.4.25.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6137-6145

Subventions

Organisme : NIAID NIH HHS
ID : R21 AI101393
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI123794
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI075045
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI075045
Pays : United States

Références

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Auteurs

Wenhu Zhan (W)

Department of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.

Joseph Visone (J)

Department of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Department of Medicine , Division of Infectious Diseases , 1300 York Avenue , New York , New York 10065 , United States.

Tierra Ouellette (T)

Department of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.

Jacob C Harris (JC)

Department of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Department of Medicine , Division of Infectious Diseases , 1300 York Avenue , New York , New York 10065 , United States.

Rong Wang (R)

NMR Analytical Core Facility , Memorial Sloan Kettering Cancer Center , 1275 York Avenue , New York , New York 10065 , United States.

Hao Zhang (H)

Department of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.

Pradeep K Singh (PK)

Chemical Core Facility, Department of Biochemistry , Weill Cornell Medicine , New York , New York 10065 , United States.

John Ginn (J)

Tri-Institutional Therapeutics Discovery Institute , 413 E. 69th Street , New York , New York 10065 , United States.

George Sukenick (G)

NMR Analytical Core Facility , Memorial Sloan Kettering Cancer Center , 1275 York Avenue , New York , New York 10065 , United States.

Tzu-Tshin Wong (TT)

Takeda Pharmaceutical Company Ltd. , 35 Landsdowne Street , Cambridge , Massachusetts 02139 , United States.

Judith I Okoro (JI)

Infectious Diseases Research Collaboration , Kampala , Uganda.

Ryan M Scales (RM)

Department of Public Health , University of North Carolina , Charlotte , North Carolina 28223 , United States.

Patrick K Tumwebaze (PK)

Infectious Diseases Research Collaboration , Kampala , Uganda.

Philip J Rosenthal (PJ)

Department of Medicine , University of California, San Francisco , San Francisco , California 94143 , United States.

Björn F C Kafsack (BFC)

Department of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.

Roland A Cooper (RA)

Department of Natural Sciences and Mathematics , Dominican University of California , San Rafael , California 94901 , United States.

Peter T Meinke (PT)

Tri-Institutional Therapeutics Discovery Institute , 413 E. 69th Street , New York , New York 10065 , United States.

Laura A Kirkman (LA)

Department of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
Department of Medicine , Division of Infectious Diseases , 1300 York Avenue , New York , New York 10065 , United States.

Gang Lin (G)

Department of Microbiology & Immunology , Weill Cornell Medicine , 1300 York Avenue , New York , New York 10065 , United States.
ORCID: 0000-0003-4797-7073

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Improvement of Asparagine Ethylenediamines as...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Asparagine › Improvement of Asparagine Ethylenediamines as...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Improvement of Asparagine Ethylenediamines as...
questionsmedicales.fr › Composés chimiques organiques › Amines › Polyamines › Diamines › Éthylènediamines › Improvement of Asparagine Ethylenediamines as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Improvement of Asparagine Ethylenediamines as...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Paludisme à Plasmodium falciparum › Improvement of Asparagine Ethylenediamines as...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Improvement of Asparagine Ethylenediamines as...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Improvement of Asparagine Ethylenediamines as...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Proteasome endopeptidase complex › Improvement of Asparagine Ethylenediamines as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Inhibiteurs du protéasome › Improvement of Asparagine Ethylenediamines as...