Antemortem histopathology and imaging findings in a case of Marchiafava-Bignami disease.
Antemortem histopathology
Corpus callosum
Demyelinating lesion
Marchiafava-Bignami disease
Journal
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
ISSN: 1532-2653
Titre abrégé: J Clin Neurosci
Pays: Scotland
ID NLM: 9433352
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
10
10
2018
revised:
17
02
2019
accepted:
08
05
2019
pubmed:
11
6
2019
medline:
30
10
2019
entrez:
11
6
2019
Statut:
ppublish
Résumé
Marchiafava-Bignami disease (MBD) is a rare condition often associated with chronic alcohol abuse. Clinical presentation is diverse. Characteristic magnetic resonance imaging (MRI) changes in the corpus callosum are the mainstay of radiological diagnosis. We present a case of a 54-year-old man with chronic alcoholism and peripherally enhancing lesion in the body of the corpus callosum on MRI Brain. Open biopsy of the lesion showed necrosis and demyelination. He was diagnosed with Marchiafava-Bignami disease based on clinical, radiology and histopathology findings. Our case represents the only case in the literature with antemortem histopathology findings describing MBD.
Identifiants
pubmed: 31178304
pii: S0967-5868(18)31568-6
doi: 10.1016/j.jocn.2019.05.009
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
273-275Informations de copyright
Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.