An Anti-PM/Scl-75 Antibody-positive Japanese Woman Who Developed Inflammatory Myopathy.
Japanese
anti-PM/Scl antibody
inflammatory myopathy
muscle biopsy
neurology
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Sep 2019
15 Sep 2019
Historique:
pubmed:
11
6
2019
medline:
26
12
2019
entrez:
11
6
2019
Statut:
ppublish
Résumé
A 69-year-old Japanese woman presented with mild muscle weakness of the neck and symmetrical proximal parts of the upper and lower limbs. Laboratory tests, needle electromyography, and a muscle biopsy revealed inflammatory myopathy with an apparent clinical classification of polymyositis and positive findings for anti-PM/Scl-75 antibody. This antibody is rare among Japanese populations, and most Japanese patients with the antibody are not classified with the inflammatory myopathy seen in polymyositis. The muscle biopsy also showed marked necrotic and regenerative fibers. We need to collectively investigate patients with the potential to develop this disease, and to identify any unique characteristics for Asian populations, including Japanese.
Identifiants
pubmed: 31178484
doi: 10.2169/internalmedicine.2402-18
pmc: PMC6794191
doi:
Substances chimiques
Autoantibodies
0
EXOSC9 protein, human
0
RNA-Binding Proteins
0
Exosome Multienzyme Ribonuclease Complex
EC 3.1.-
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2689-2693Références
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