Effort-based decision-making is affected by overweight/obesity in major depressive disorder.

Adult Anhedonia / physiology Body Mass Index Decision Making / physiology Depressive Disorder, Major / complications Female Humans Male Motivation Obesity / physiopathology Reward
Anhedonia Insulin Major depressive disorder Obesity Reward

Journal

Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073

Informations de publication

Date de publication:
01 09 2019
Historique:
received: 01 03 2019
revised: 09 04 2019
accepted: 02 06 2019
pubmed: 11 6 2019
medline: 12 6 2020
entrez: 11 6 2019
Statut: ppublish

Résumé

Anhedonia and abnormalities in reward behavior are core features of major depressive disorder (MDD). Convergent evidence indicates that overweight/obesity (OW), a highly prevalent condition in MDD, is independently associated with reward disturbances. We therefore aimed to investigate the moderating effect of OW on the willingness to expend efforts for reward in individuals with MDD and healthy controls (HC). Forty-one adults (HC n = 20, MDD n = 21) completed the Effort Expenditure for Rewards Task (EEfRT), clinical and cognitive measures. Anthropometric parameters were assessed in all participants, and an additional evaluation of laboratorial parameters were conducted solely on those with MDD. Individuals with MDD were all on vortioxetine monotherapy (10-20 mg/day). Interactions between reward magnitude, group and OW were observed (χ OW significantly moderated the association between MDD and willingness to make efforts for rewards. These findings offer novel evidence on the potential role of metabolic factors on the basis of anhedonia, and for the heuristic models proposing a pathophysiological connection between mood and metabolic disorders.

Sections du résumé

BACKGROUND
Anhedonia and abnormalities in reward behavior are core features of major depressive disorder (MDD). Convergent evidence indicates that overweight/obesity (OW), a highly prevalent condition in MDD, is independently associated with reward disturbances. We therefore aimed to investigate the moderating effect of OW on the willingness to expend efforts for reward in individuals with MDD and healthy controls (HC).
METHODS
Forty-one adults (HC n = 20, MDD n = 21) completed the Effort Expenditure for Rewards Task (EEfRT), clinical and cognitive measures. Anthropometric parameters were assessed in all participants, and an additional evaluation of laboratorial parameters were conducted solely on those with MDD. Individuals with MDD were all on vortioxetine monotherapy (10-20 mg/day).
RESULTS
Interactions between reward magnitude, group and OW were observed (χ
CONCLUSIONS
OW significantly moderated the association between MDD and willingness to make efforts for rewards. These findings offer novel evidence on the potential role of metabolic factors on the basis of anhedonia, and for the heuristic models proposing a pathophysiological connection between mood and metabolic disorders.

Identifiants

DOI: 10.1016/j.jad.2019.06.002 PMID: 31181378
pubmed: 31181378
pii: S0165-0327(19)30547-6
doi: 10.1016/j.jad.2019.06.002
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

221-227

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Rodrigo B Mansur (RB)

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, M5T 2S8, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, M5T 2S8, Canada. Electronic address: rodrigo.mansur@uhn.ca.

Mehala Subramaniapillai (M)

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, M5T 2S8, Canada.

Hannah Zuckerman (H)

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, M5T 2S8, Canada.

Caroline Park (C)

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, M5T 2S8, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, M5T 2S8, Canada.

Michelle Iacobucci (M)

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, M5T 2S8, Canada.

Yena Lee (Y)

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, M5T 2S8, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, M5T 2S8, Canada.

Maria Tuineag (M)

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, M5T 2S8, Canada.

Colin Hawco (C)

Department of Psychiatry, University of Toronto, Toronto, ON, M5T 2S8, Canada; Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, Canada.

Benicio N Frey (BN)

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Ontario, Canada.

Natalie Rasgon (N)

Center for Neuroscience in Women's Health, Stanford University, Palo Alto, USA.

Elisa Brietzke (E)

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, M5T 2S8, Canada; Department of Psychiatry, Queen's University, Kingston, ON, K7L 7X3, Canada; Research Group in Molecular and Behavioral Neurosciences of Mood Disorders, Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, SP, 04038-000, Brazil.

Roger S McIntyre (RS)

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, M5T 2S8, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, M5T 2S8, Canada; Research Group in Molecular and Behavioral Neurosciences of Mood Disorders, Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, SP, 04038-000, Brazil; Brain and Cognition Discovery Foundation, Mississauga, ON L5C 4E, Canada.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Effort-based decision-making is affected by...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Anhédonie › Effort-based decision-making is affected by...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Effort-based decision-making is affected by...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Pensée (activité mentale) › Prise de décision › Effort-based decision-making is affected by...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Effort-based decision-making is affected by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effort-based decision-making is affected by...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Personnalité › Intelligence › Intelligence émotionnelle › Motivation › Effort-based decision-making is affected by...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Effort-based decision-making is affected by...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Renforcement (psychologie) › Récompense › Effort-based decision-making is affected by...