Petunidin, a B-ring 5'-
Animals
Anthocyanins
/ pharmacology
Bone Density Conservation Agents
/ pharmacology
Bone Morphogenetic Protein 2
/ metabolism
Cancellous Bone
/ drug effects
Female
Matrix Metalloproteinases
/ metabolism
Mice
Mice, Inbred C57BL
Osteoblasts
/ drug effects
Osteogenesis
Osteoporosis
/ drug therapy
RANK Ligand
/ metabolism
RAW 264.7 Cells
anthocyanin
bone anabolism
osteoblast
osteoclast
osteoporosis
petunidin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Jun 2019
07 Jun 2019
Historique:
received:
15
05
2019
revised:
03
06
2019
accepted:
05
06
2019
entrez:
12
6
2019
pubmed:
12
6
2019
medline:
19
11
2019
Statut:
epublish
Résumé
Several lines of evidence suggest that oxidative stress is one of the key pathogenic mechanisms of osteoporosis. We aimed to elucidate the bone protective effects of petunidin, one of the most common anthocyanidins, considering its potent antioxidative activity. Petunidin (>5 μg/mL) significantly inhibited osteoclastogenesis and downregulated
Identifiants
pubmed: 31181661
pii: ijms20112795
doi: 10.3390/ijms20112795
pmc: PMC6600628
pii:
doi:
Substances chimiques
Anthocyanins
0
Bmp2 protein, mouse
0
Bone Density Conservation Agents
0
Bone Morphogenetic Protein 2
0
RANK Ligand
0
Tnfsf11 protein, mouse
0
Matrix Metalloproteinases
EC 3.4.24.-
petunidin
WRK4Q8K2D8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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