Neuronal cell-subtype specificity of neural synchronization in mouse primary visual cortex.
Animals
Calcium
/ metabolism
Electrophysiology
Evoked Potentials, Visual
Female
Interneurons
/ physiology
Male
Mice, Transgenic
Microscopy, Fluorescence, Multiphoton
Neurons
/ physiology
Parvalbumins
/ metabolism
Photic Stimulation
Somatostatin
/ metabolism
Vasoactive Intestinal Peptide
/ metabolism
Visual Cortex
/ cytology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 06 2019
10 06 2019
Historique:
received:
26
01
2019
accepted:
27
04
2019
entrez:
12
6
2019
pubmed:
12
6
2019
medline:
5
7
2019
Statut:
epublish
Résumé
Spatiotemporally synchronised neuronal activity is central to sensation, motion and cognition. Brain circuits consist of dynamically interconnected neuronal cell-types, thus elucidating how neuron types synergise within the network is key to understand the neuronal orchestra. Here we show that in neocortex neuron-network coupling is neuronal cell-subtype specific. Employing in vivo two-photon (2-p) Calcium (Ca) imaging and 2-p targeted whole-cell recordings, we cell-type specifically investigated the coupling profiles of genetically defined neuron populations in superficial layers (L) of mouse primary visual cortex (V1). Our data reveal novel subtlety of neuron-network coupling in inhibitory interneurons (INs). Parvalbumin (PV)- and Vasoactive intestinal peptide (VIP)-expressing INs exhibit skewed distributions towards strong network-coupling; in Somatostatin (SST)-expressing INs, however, two physiological subpopulations are identified with distinct neuron-network coupling profiles, providing direct evidence for subtype specificity. Our results thus add novel functional granularity to neuronal cell-typing, and provided insights critical to simplifying/understanding neural dynamics.
Identifiants
pubmed: 31182715
doi: 10.1038/s41467-019-10498-1
pii: 10.1038/s41467-019-10498-1
pmc: PMC6557841
doi:
Substances chimiques
Parvalbumins
0
Vasoactive Intestinal Peptide
37221-79-7
Somatostatin
51110-01-1
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2533Subventions
Organisme : NEI NIH HHS
ID : R01 EY023173
Pays : United States
Organisme : NIMH NIH HHS
ID : U19 MH114830
Pays : United States
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