Induction of anti-cancer T cell immunity by in situ vaccination using systemically administered nanomedicines.
Chemotherapeutic and immunostimulant
Immunogenic cell death
Nanomedicine and biomaterials
Nanoparticle and microparticle
Pattern recognition receptor
Journal
Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053
Informations de publication
Date de publication:
10 09 2019
10 09 2019
Historique:
received:
16
01
2019
revised:
31
05
2019
accepted:
04
06
2019
pubmed:
12
6
2019
medline:
11
6
2020
entrez:
12
6
2019
Statut:
ppublish
Résumé
Patients with inadequate anti-cancer T cell responses experience limited benefit from immune checkpoint inhibitors and other immunotherapies that require T cells. Therefore, treatments that induce de novo anti-cancer T cell immunity are needed. One strategy - referred to as in situ vaccination - is to deliver chemotherapeutic or immunostimulatory drugs into tumors to promote cancer cell death and provide a stimulatory environment for priming T cells against antigens already present in the tumor. However, achieving sufficient drug concentrations in tumors without causing dose-limiting toxicities remains a major challenge. To address this challenge, nanomedicines based on nano-sized carriers ('nanocarriers') of chemotherapeutics and immunostimulants are being developed to improve drug accumulation in tumors following systemic (intravenous) administration. Herein, we present the rationale for using systemically administrable nanomedicines to induce anti-cancer T cell immunity via in situ vaccination and provide an overview of synthetic nanomedicines currently used clinically. We also describe general strategies for improving nanomedicine design to increase tumor uptake, including use of micelle- and star polymer-based nanocarriers. We conclude with perspectives for how nanomedicine properties, host factors and treatment combinations can be leveraged to maximize efficacy.
Identifiants
pubmed: 31185250
pii: S0304-3835(19)30349-0
doi: 10.1016/j.canlet.2019.114427
pmc: PMC6629511
mid: NIHMS1532079
pii:
doi:
Substances chimiques
Adjuvants, Immunologic
0
Cancer Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
192-203Subventions
Organisme : BLRD VA
ID : I01 BX003690
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB027143
Pays : United States
Informations de copyright
Published by Elsevier B.V.
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