Neuropsychiatric Symptoms as Risk Factors for Cognitive Decline in Clinically Normal Older Adults: The Cache County Study.
Aged
Aged, 80 and over
Aging
/ physiology
Alzheimer Disease
/ epidemiology
Anxiety
/ epidemiology
Behavioral Symptoms
/ epidemiology
Case-Control Studies
Cognitive Dysfunction
/ epidemiology
Dementia
/ epidemiology
Depression
/ epidemiology
Female
Humans
Longitudinal Studies
Male
Neuropsychological Tests
Psychiatric Status Rating Scales
Risk Factors
Utah
/ epidemiology
Alzheimer's disease
Neuropsychiatric symptoms
dementia
mild cognitive impairment
Journal
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
ISSN: 1545-7214
Titre abrégé: Am J Geriatr Psychiatry
Pays: England
ID NLM: 9309609
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
19
06
2018
revised:
17
02
2019
accepted:
18
03
2019
pubmed:
13
6
2019
medline:
5
1
2021
entrez:
13
6
2019
Statut:
ppublish
Résumé
There has been considerable progress in identifying early cognitive and biomarker predictors of Alzheimer's disease (AD). Neuropsychiatric symptoms (NPS) are common in AD and appear to predict progression after the onset of mild cognitive impairment or dementia. The objective of the study is to examine the relationship between NPS in clinically normal older adults and subsequent cognitive decline in a population-based sample. The Cache County Study on Memory in Aging consists of a population-based sample of 5,092 older adults. We identified 470 clinically normal adults who were followed for an average period of 5.73 years. NPS were evaluated at the baseline clinical assessment using the Neuropsychiatric Inventory (NPI). NPI domain scores were quantified as the product of frequency X severity in individual NPI domains, and then summed for the NPI-Total. Neuropsychological measures were collected at baseline and at each subsequent follow-up wave. Linear mixed-effects models assessed the association of NPI-Total, NPI-Depression, and NPI-Anxiety scores (obtained at baseline) on longitudinal change in neuropsychological performance, controlling for age, sex, and education. Baseline NPI-Total score was associated with a more rapid rate of decline in word list memory, praxis recall, and animal fluency. Baseline NPI-Depression was not associated with later decline on any of the cognitive tests, while baseline NPI-Anxiety was associated with decline in Symbol Digit Modality. In conclusion, among clinically normal older adults derived from this population-based study, total burden of NPS was associated with longitudinal cognitive decline. These results add to the evidence that NPS are risk factors for or clinical indicators of preclinical dementia syndrome. Our study was an exploratory study and we did not control for multiple comparisons.
Identifiants
pubmed: 31186157
pii: S1064-7481(19)30368-9
doi: 10.1016/j.jagp.2019.03.023
pmc: PMC6874723
mid: NIHMS1530131
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
64-71Subventions
Organisme : NIA NIH HHS
ID : R01 AG021136
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
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