Genomic Identification of the TOR Signaling Pathway as a Target of the Plant Alkaloid Antofine in the Phytopathogen Fusarium graminearum.
Fusarium
drug targets
rapamycin
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
11 06 2019
11 06 2019
Historique:
entrez:
13
6
2019
pubmed:
13
6
2019
medline:
25
1
2020
Statut:
epublish
Résumé
Antofine, a phenanthroindolizidine alkaloid, is a bioactive natural product isolated from milkweeds that exhibits numerous biological activities, including anticancer, antimicrobial, antiviral, and anti-inflammatory properties. However, the direct targets and mode of action of antofine have not been determined. In this report, we show that antofine displays antifungal properties against the phytopathogen
Identifiants
pubmed: 31186319
pii: mBio.00792-19
doi: 10.1128/mBio.00792-19
pmc: PMC6561021
pii:
doi:
Substances chimiques
Fungicides, Industrial
0
Indoles
0
Phenanthrolines
0
antofine
0
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Crown copyright 2019.
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