Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review.


Journal

Stem cells translational medicine
ISSN: 2157-6580
Titre abrégé: Stem Cells Transl Med
Pays: England
ID NLM: 101578022

Informations de publication

Date de publication:
10 2019
Historique:
received: 14 03 2019
accepted: 19 05 2019
pubmed: 13 6 2019
medline: 27 6 2020
entrez: 13 6 2019
Statut: ppublish

Résumé

Accumulating evidence indicates that stem cells (SCs) possess immunomodulatory, anti-inflammatory, and prohealing properties. The mechanisms underlying these functions are being investigated with the final goal to set a solid background for the clinical use of SCs and/or their derivatives. Specialized proresolving lipid mediators (SPMs) are small lipids formed by the enzymatic metabolism of polyunsaturated fatty acids. They represent a leading class of molecules that actively and timely regulate the resolution of inflammation and promote tissue/organ repair. SC formation of these mediators as well as expression of their receptors has been recently reported, suggesting that SPMs may be involved in the immunomodulatory, proresolving functions of SCs. In the present review, we summarize the current knowledge on SPMs in SCs, focusing on biosynthetic pathways, receptors, and bioactions, with the intent to provide an integrated view of SPM impact on SC biology. Stem Cells Translational Medicine 2019;8:992-998.

Identifiants

pubmed: 31187940
doi: 10.1002/sctm.19-0078
pmc: PMC6766599
doi:

Substances chimiques

Inflammation Mediators 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

992-998

Informations de copyright

© 2019 The Authors. Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

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Auteurs

Mario Romano (M)

Department of Medical, Oral, and Biotechnological Sciences, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.
StemTech Group, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Center on Aging Sciences and Translational Medicine (CeSI-MeT), "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.

Sara Patruno (S)

Department of Medical, Oral, and Biotechnological Sciences, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.
StemTech Group, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Center on Aging Sciences and Translational Medicine (CeSI-MeT), "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.

Antonella Pomilio (A)

Department of Medical, Oral, and Biotechnological Sciences, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.
StemTech Group, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Center on Aging Sciences and Translational Medicine (CeSI-MeT), "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.

Antonio Recchiuti (A)

Department of Medical, Oral, and Biotechnological Sciences, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Center on Aging Sciences and Translational Medicine (CeSI-MeT), "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.

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