Common Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization.
GWAS
HLA
SIRPG
meningococcal disease
persistence of immunity
vaccine-induced immunity
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
11 06 2019
11 06 2019
Historique:
received:
22
10
2018
revised:
25
01
2019
accepted:
15
05
2019
entrez:
13
6
2019
pubmed:
13
6
2019
medline:
4
8
2020
Statut:
ppublish
Résumé
Vaccines have revolutionized public health, preventing millions of deaths each year, particularly in childhood. Yet, there is considerable variability in the magnitude and persistence of vaccine-induced immunity. Maintenance of specific antibody is essential for continuity of vaccine-induced serological protection. We conducted a genome-wide association study into the persistence of immunity to three childhood vaccines: capsular group C meningococcal (MenC), Haemophilus influenzae type b, and tetanus toxoid (TT) vaccines. We detail associations between variants in a locus containing a family of signal-regulatory proteins and the persistence MenC immunity. We postulate a regulatory role for the lead SNP, with supporting epigenetic and expression quantitative trait loci data. Furthermore, we define associations between SNPs in the human leukocyte antigen (HLA) locus and the persistence of TT-specific immunity. Moreover, we describe four classical HLA alleles, HLA DRB1
Identifiants
pubmed: 31189108
pii: S2211-1247(19)30682-5
doi: 10.1016/j.celrep.2019.05.053
pii:
doi:
Substances chimiques
HLA Antigens
0
Haemophilus Vaccines
0
Meningococcal Vaccines
0
Tetanus Toxoid
0
serogroup C meningococcal conjugate vaccine
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3241-3253.e4Subventions
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.