Mapping versus source methods for quantifying myocardial T1 in controls and in repaired tetralogy of Fallot: interchangeability and reproducibility in children.
Children
Heart
Magnetic resonance imaging
Post-processing
Relaxometry
Reproducibility
T1 mapping
Tetralogy of Fallot
Journal
Pediatric radiology
ISSN: 1432-1998
Titre abrégé: Pediatr Radiol
Pays: Germany
ID NLM: 0365332
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
29
11
2018
accepted:
14
05
2019
revised:
03
04
2019
pubmed:
14
6
2019
medline:
1
7
2020
entrez:
14
6
2019
Statut:
ppublish
Résumé
Myocardial T1 relaxometry can be performed by contouring on individual T1-weighted source images (source method) or on a single T1 map (mapping method). This study compares (a) agreement between native T1 and extracellular volume results of the two methods and (b) interobserver reproducibility of the two methods in children without heart disease and those with tetralogy of Fallot (TOF). We retrospectively analyzed pediatric patients (controls and those with repaired TOF) with cardiac magnetic resonance examinations including extracellular volume quantification using the modified Look-Locker inversion recovery (MOLLI) sequence. We compared native T1 and extracellular volume of the entire left ventricle and interventricular septum derived using the source and the mapping approaches. In the control group (n=25, median age 14.0 years, interquartile range [IQR] 11.5-16.5 years), the mapping method produced lower native T1 values than the source method in the interventricular septum (mean difference ± standard deviation [SD] = 12±15 ms, P<0.001). In the TOF group (n=50, median age 13.3 years, IQR 9.9-15.0 years), the mapping method produced lower values for native T1 and extracellular volume in the interventricular septum (mean difference 9±14 ms and 0.6±1.1%, P<0.001). In 6-12% of the children, differences were >3 standard deviations from the mean difference. Interobserver reproducibility between the two methods by intraclass correlation coefficients were clinically equivalent. T1 and extracellular volume values generated by the source and mapping methods show systematic differences and can vary significantly in an individual child, and thus cannot be used interchangeably in clinical practice. The source method might allow for easier detection and, in some cases, mitigation of artifacts that are not infrequent in children and can be difficult to appreciate on the T1 map.
Sections du résumé
BACKGROUND
Myocardial T1 relaxometry can be performed by contouring on individual T1-weighted source images (source method) or on a single T1 map (mapping method).
OBJECTIVE
This study compares (a) agreement between native T1 and extracellular volume results of the two methods and (b) interobserver reproducibility of the two methods in children without heart disease and those with tetralogy of Fallot (TOF).
MATERIALS AND METHODS
We retrospectively analyzed pediatric patients (controls and those with repaired TOF) with cardiac magnetic resonance examinations including extracellular volume quantification using the modified Look-Locker inversion recovery (MOLLI) sequence. We compared native T1 and extracellular volume of the entire left ventricle and interventricular septum derived using the source and the mapping approaches.
RESULTS
In the control group (n=25, median age 14.0 years, interquartile range [IQR] 11.5-16.5 years), the mapping method produced lower native T1 values than the source method in the interventricular septum (mean difference ± standard deviation [SD] = 12±15 ms, P<0.001). In the TOF group (n=50, median age 13.3 years, IQR 9.9-15.0 years), the mapping method produced lower values for native T1 and extracellular volume in the interventricular septum (mean difference 9±14 ms and 0.6±1.1%, P<0.001). In 6-12% of the children, differences were >3 standard deviations from the mean difference. Interobserver reproducibility between the two methods by intraclass correlation coefficients were clinically equivalent.
CONCLUSION
T1 and extracellular volume values generated by the source and mapping methods show systematic differences and can vary significantly in an individual child, and thus cannot be used interchangeably in clinical practice. The source method might allow for easier detection and, in some cases, mitigation of artifacts that are not infrequent in children and can be difficult to appreciate on the T1 map.
Identifiants
pubmed: 31190110
doi: 10.1007/s00247-019-04428-y
pii: 10.1007/s00247-019-04428-y
doi:
Substances chimiques
Contrast Media
0
Organometallic Compounds
0
gadobutrol
1BJ477IO2L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1152-1162Références
J Cardiovasc Magn Reson. 2017 Oct 9;19(1):75
pubmed: 28992817
Eur Heart J Cardiovasc Imaging. 2013 Oct;14(10):963-8
pubmed: 23389732
Circulation. 2014 Jul 1;130(1):79-86
pubmed: 24982119
J Cardiovasc Magn Reson. 2014 Dec 05;16:99
pubmed: 25475749
Circ Cardiovasc Imaging. 2015 Feb;8(2):e002504
pubmed: 25657297
J Cardiovasc Magn Reson. 2012 Dec 28;14:90
pubmed: 23272704
Magn Reson Med. 2014 Apr;71(4):1428-34
pubmed: 23722695
JACC Cardiovasc Imaging. 2016 Jan;9(1):1-10
pubmed: 26684969
J Cardiovasc Magn Reson. 2013 Jun 18;15:53
pubmed: 23777327
Int J Cardiol. 2017 Aug 1;240:172-177
pubmed: 28461021
Circ Cardiovasc Imaging. 2010 Nov;3(6):727-34
pubmed: 20855860
J Chiropr Med. 2016 Jun;15(2):155-63
pubmed: 27330520
J Cardiovasc Magn Reson. 2012 Sep 10;14:63
pubmed: 22963517
Magn Reson Med. 2012 Jun;67(6):1644-55
pubmed: 22135227
J Magn Reson Imaging. 2015 Jun;41(6):1505-11
pubmed: 25104503
Eur Heart J Cardiovasc Imaging. 2015 Jul;16(7):763-70
pubmed: 25680382
J Cardiovasc Magn Reson. 2013 Sep 11;15:78
pubmed: 24025486
Radiology. 2006 Mar;238(3):1004-12
pubmed: 16424239
J Am Coll Cardiol. 2014 May 6;63(17):1778-85
pubmed: 24632273
J Cardiovasc Magn Reson. 2012 Jun 21;14:42
pubmed: 22720998
Circ Cardiovasc Imaging. 2017 Mar;10(3):
pubmed: 28292861
J Cardiovasc Magn Reson. 2015 Jun 11;17:48
pubmed: 26062931
J Cardiovasc Magn Reson. 2012 Sep 11;14:64
pubmed: 22967246
J Cardiovasc Magn Reson. 2013 Jun 21;15:56
pubmed: 23800276
J Cardiovasc Magn Reson. 2017 Feb 1;19(1):10
pubmed: 28143545
Radiographics. 2014 Mar-Apr;34(2):377-95
pubmed: 24617686