The GluTR-binding protein is the heme-binding factor for feedback control of glutamyl-tRNA reductase.
5-aminolevulinic acid synthesis
A. thaliana
GluTR
cell biology
heme
plant biology
posttranslational regulation
tetrapyrrole biosynthesis
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
13 06 2019
13 06 2019
Historique:
received:
21
02
2019
accepted:
12
06
2019
pubmed:
14
6
2019
medline:
20
2
2020
entrez:
14
6
2019
Statut:
epublish
Résumé
Synthesis of 5-aminolevulinic acid (ALA) is the rate-limiting step in tetrapyrrole biosynthesis in land plants. In photosynthetic eukaryotes and many bacteria, glutamyl-tRNA reductase (GluTR) is the most tightly controlled enzyme upstream of ALA. Higher plants possess two GluTR isoforms: GluTR1 is predominantly expressed in green tissue, and GluTR2 is constitutively expressed in all organs. Although proposed long time ago, the molecular mechanism of heme-dependent inhibition of GluTR
Identifiants
pubmed: 31194674
doi: 10.7554/eLife.46300
pii: 46300
pmc: PMC6597238
doi:
pii:
Substances chimiques
Arabidopsis Proteins
0
Carrier Proteins
0
glutamyl-tRNA reductase-binding protein, Arabidopsis
0
Heme
42VZT0U6YR
Aminolevulinic Acid
88755TAZ87
Aldehyde Oxidoreductases
EC 1.2.-
glutamyl-tRNA reductase, Arabidopsis
EC 1.2.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 317556048
Pays : International
Informations de copyright
© 2019, Richter et al.
Déclaration de conflit d'intérêts
AR, CB, BG No competing interests declared
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