A facile one pot synthesis of novel pyrimidine derivatives of 1,5-benzodiazepines via domino reaction and their antibacterial evaluation.

Anti-Bacterial Agents / chemical synthesis Benzodiazepines / chemical synthesis Cell Wall / drug effects Escherichia coli / drug effects Microbial Sensitivity Tests Pyrimidines / chemical synthesis Staphylococcus aureus / drug effects
1,5-benzodiazepine Antibacterial activity Bacteria Domino approach Pyrimidine compounds

Journal

Journal of microbiological methods
ISSN: 1872-8359
Titre abrégé: J Microbiol Methods
Pays: Netherlands
ID NLM: 8306883

Informations de publication

Date de publication:
08 2019
Historique:
received: 03 03 2019
revised: 02 06 2019
accepted: 02 06 2019
pubmed: 14 6 2019
medline: 17 6 2020
entrez: 14 6 2019
Statut: ppublish

Résumé

A new series of pyrimidine (8, 14, 18 and 23) embellished analogues of 1,5-benzodiazepines were synthesized by the one-pot domino approach using the catalyst DABCO (1,4-diazabicyclo[2.2.2]octane). For each compound synthesized, anti-microbial efficacy was determined using broth microdilution assay and half maximal inhibitory concentration (IC

Identifiants

DOI: 10.1016/j.mimet.2019.105648 PMID: 31195033
pubmed: 31195033
pii: S0167-7012(19)30168-X
doi: 10.1016/j.mimet.2019.105648
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Pyrimidines 0
Benzodiazepines 12794-10-4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105648

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Apoorva Misra (A)

Department of Chemistry, Banasthali Vidyapith, Rajasthan 304022, India.

Sonika Jain (S)

Department of Chemistry, Banasthali Vidyapith, Rajasthan 304022, India.

Dharma Kishore (D)

Department of Chemistry, Banasthali Vidyapith, Rajasthan 304022, India.

Vivek Dave (V)

Department of Pharmacy, Banasthali Banasthali Vidyapith, Rajasthan 304022, India.

Kakarla Raghava Reddy (KR)

School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW 2006, Australia.

Veera Sadhu (V)

School of Physical Sciences, Banasthali Vidyapith, Rajasthan, 304022, India. Electronic address: veera.sadhu@gmail.com.

Jaya Dwivedi (J)

Department of Chemistry, Banasthali Vidyapith, Rajasthan 304022, India. Electronic address: jayadwivedi@yahoo.co.in.

Swapnil Sharma (S)

Department of Pharmacy, Banasthali Banasthali Vidyapith, Rajasthan 304022, India.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › A facile one pot synthesis of novel pyrimidine...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › A facile one pot synthesis of novel pyrimidine...
questionsmedicales.fr › Cellules › Structures cellulaires › Paroi cellulaire › A facile one pot synthesis of novel pyrimidine...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › A facile one pot synthesis of novel pyrimidine...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › A facile one pot synthesis of novel pyrimidine...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › A facile one pot synthesis of novel pyrimidine...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › A facile one pot synthesis of novel pyrimidine...