MR and PET-CT monitoring of tissue-engineered vascular grafts in the ovine carotid artery.

Animals Blood Vessel Prosthesis Carotid Arteries / diagnostic imaging Contrast Media / analysis Dextrans / analysis Magnetic Resonance Imaging / methods Magnetite Nanoparticles / analysis Positron Emission Tomography Computed Tomography / methods Sheep
MRI Multimodal monitoring Non-invasive monitoring PET-CT Tissue-engineered vascular graft USPIO

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
09 2019
Historique:
received: 11 12 2018
revised: 16 05 2019
accepted: 25 05 2019
pubmed: 14 6 2019
medline: 2 10 2020
entrez: 14 6 2019
Statut: ppublish

Résumé

The modification of biomaterials to comply with clinically employed monitoring techniques is a promising strategy to support clinical translation in regenerative medicine. Here, multimodal imaging of tissue-engineered vascular grafts (TEVG) was enabled by functionalizing the textile scaffold with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles. The resulting MR-imageable grafts (iTEVG) were monitored non-invasively throughout their whole life-cycle, from initial quality control to longitudinal functional evaluation in an ovine model for up to 8 weeks. Crucial features such as the complete embedding of the textile mesh in the developing tissue and the grafts' structural stability were assessed in vitro using 1T-, 3T- and 7T-MRI scanners. In vivo, the grafts were imaged by 3T-MRI and PET-CT. Contrary to unlabeled constructs, iTEVG could be delineated from native arteries and precisely localized by MRI. USPIO labeling neither induced calcifications, nor negatively affected their remodeling with respect to tissue-specific extracellular matrix composition and endothelialization. Functionality was confirmed by MR-angiography.

Identifiants

DOI: 10.1016/j.biomaterials.2019.119228 PMID: 31195299
pubmed: 31195299
pii: S0142-9612(19)30327-8
doi: 10.1016/j.biomaterials.2019.119228
pii:
doi:

Substances chimiques

Contrast Media 0
Dextrans 0
Magnetite Nanoparticles 0
ferumoxtran-10 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

119228

Subventions

Organisme : European Research Council
ID : 309495
Pays : International

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Frederic Wolf (F)

Dept. of Biohybrid & Medical Textiles (BioTex), Institute of Applied Medical Engineering (AME), Helmholtz Institute Aachen and Institute for Textiles Engineering (ITA), RWTH Aachen University, Forckenbeckstr. 55, 52074, Aachen, Germany.

Vera Paefgen (V)

Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Forckenbeckstr. 55, 52074 Aachen, Germany.

Oliver Winz (O)

Department of Nuclear Medicine, University Hospital RWTH Aachen, 52074, Pauwelsstr. 30, 52074 Aachen, Germany.

Marianne Mertens (M)

Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Forckenbeckstr. 55, 52074 Aachen, Germany.

Sabine Koch (S)

Dept. of Biohybrid & Medical Textiles (BioTex), Institute of Applied Medical Engineering (AME), Helmholtz Institute Aachen and Institute for Textiles Engineering (ITA), RWTH Aachen University, Forckenbeckstr. 55, 52074, Aachen, Germany.

Nicolas Gross-Weege (N)

Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Forckenbeckstr. 55, 52074 Aachen, Germany.

Agnieszka Morgenroth (A)

Department of Nuclear Medicine, University Hospital RWTH Aachen, 52074, Pauwelsstr. 30, 52074 Aachen, Germany.

Anne Rix (A)

Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Forckenbeckstr. 55, 52074 Aachen, Germany.

Heike Schnoering (H)

Clinic for Thoracic and Cardiovascular Surgery, University Hospital Aachen, Pauwelsstr. 30, 52074 Aachen, Germany.

Khaled Chalabi (K)

Institut National de Chirurgie Cardiaque et de Cardiologie Interventionnelle, 2A, rue Nicolas Ernest Barblé, 1210 Luxembourg, Luxembourg.

Stefan Jockenhoevel (S)

Dept. of Biohybrid & Medical Textiles (BioTex), Institute of Applied Medical Engineering (AME), Helmholtz Institute Aachen and Institute for Textiles Engineering (ITA), RWTH Aachen University, Forckenbeckstr. 55, 52074, Aachen, Germany. Electronic address: jockenhoevel@ame.rwth-aachen.de.

Twan Lammers (T)

Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Forckenbeckstr. 55, 52074 Aachen, Germany; Department of Targeted Therapeutics, University of Twente, PO Box 217, 7500 AE Enschede, the Netherlands.

Felix Mottaghy (F)

Department of Nuclear Medicine, University Hospital RWTH Aachen, 52074, Pauwelsstr. 30, 52074 Aachen, Germany; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center (MUMC+), P.O. Box 5800, 6202 AZ Maastricht, the Netherlands.

Fabian Kiessling (F)

Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Forckenbeckstr. 55, 52074 Aachen, Germany.

Petra Mela (P)

Dept. of Biohybrid & Medical Textiles (BioTex), Institute of Applied Medical Engineering (AME), Helmholtz Institute Aachen and Institute for Textiles Engineering (ITA), RWTH Aachen University, Forckenbeckstr. 55, 52074, Aachen, Germany. Electronic address: mela@ame.rwth-aachen.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › MR and PET-CT monitoring of tissue-engineered...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Prothèse vasculaire › MR and PET-CT monitoring of tissue-engineered...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artères carotides › MR and PET-CT monitoring of tissue-engineered...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits de contraste › MR and PET-CT monitoring of tissue-engineered...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Dextrane › MR and PET-CT monitoring of tissue-engineered...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › MR and PET-CT monitoring of tissue-engineered...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanoparticules métalliques › Nanoparticules magnétiques d'oxyde de fer › Nanoparticules de magnétite › MR and PET-CT monitoring of tissue-engineered...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › MR and PET-CT monitoring of tissue-engineered...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis › MR and PET-CT monitoring of tissue-engineered...