Mixture effect of arsenic and fluoride at environmentally relevant concentrations in zebrafish (Danio rerio) liver: Expression pattern of Nrf2 and related xenobiotic metabolizing enzymes.
Animals
Arsenic
/ toxicity
Catalase
/ metabolism
Fluorides
/ toxicity
Gene Expression Regulation
/ drug effects
Glutathione
/ metabolism
Glutathione Peroxidase
/ metabolism
Liver
/ drug effects
NF-E2-Related Factor 2
/ genetics
Oxidative Stress
/ drug effects
RNA, Messenger
/ genetics
Reactive Oxygen Species
/ metabolism
Superoxide Dismutase
/ metabolism
Thiobarbituric Acid Reactive Substances
/ metabolism
Water Pollutants, Chemical
/ toxicity
Xenobiotics
/ metabolism
Zebrafish
/ genetics
Zebrafish Proteins
/ genetics
Antagonism
Co-exposure
Nrf2
Oxidative stress
Xenobiotic metabolizing enzymes
Zebrafish
Journal
Aquatic toxicology (Amsterdam, Netherlands)
ISSN: 1879-1514
Titre abrégé: Aquat Toxicol
Pays: Netherlands
ID NLM: 8500246
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
12
04
2019
revised:
02
06
2019
accepted:
02
06
2019
pubmed:
14
6
2019
medline:
26
9
2019
entrez:
14
6
2019
Statut:
ppublish
Résumé
Nrf2 is a crucial transcription factor that regulates the expression of cytoprotective enzymes and controls cellular redox homeostasis. Both arsenic and fluoride are potent toxicants that are known to induce Nrf2. They are reported to coexist in many areas of the world leading to complex mixture effects in exposed organisms. The present study investigated the expression of Nrf2 and related xenobiotic metabolizing enzymes along with other stress markers such as histopathological alterations, catalase activity, reduced glutathione content and lipid peroxidation in zebrafish liver as a function of combined exposure to environmentally relevant concentrations of arsenic (37.87 μgL
Identifiants
pubmed: 31195325
pii: S0166-445X(19)30294-2
doi: 10.1016/j.aquatox.2019.06.002
pii:
doi:
Substances chimiques
NF-E2-Related Factor 2
0
RNA, Messenger
0
Reactive Oxygen Species
0
Thiobarbituric Acid Reactive Substances
0
Water Pollutants, Chemical
0
Xenobiotics
0
Zebrafish Proteins
0
Catalase
EC 1.11.1.6
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Glutathione
GAN16C9B8O
Arsenic
N712M78A8G
Fluorides
Q80VPU408O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105219Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.