CSPG4-Specific CAR T Cells for High-Risk Childhood B Cell Precursor Leukemia.
CAR T cells
CSPG4
MLL-translocated leukemias
back-up target antigen
high-risk childhood B cell precursor leukemia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
05 Jun 2019
05 Jun 2019
Historique:
received:
16
04
2019
revised:
24
05
2019
accepted:
27
05
2019
entrez:
15
6
2019
pubmed:
15
6
2019
medline:
4
12
2019
Statut:
epublish
Résumé
The advent of CD19-specific chimeric antigen receptor (CAR) T cells has proven to be a powerful asset in the arsenal of cancer immunotherapy of acute lymphoblastic leukemia and certain B cell lymphomas. However, a sizable portion of patients treated with CD19-CAR T cells relapse with CD19-negative cancer cells, necessitating the quest for back-up antigens. Chondroitin sulfate proteoglycan 4 (CSPG4) expression has been reported on leukemic blasts bearing the ill-fated
Identifiants
pubmed: 31195686
pii: ijms20112764
doi: 10.3390/ijms20112764
pmc: PMC6600602
pii:
doi:
Substances chimiques
Antigens
0
Antigens, Neoplasm
0
Cytokines
0
Proteoglycans
0
chondroitin sulfate proteoglycan 4
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHA 1247/3-1
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