Paraventricular Thalamus Projection Neurons Integrate Cortical and Hypothalamic Signals for Cue-Reward Processing.
Animals
Association Learning
/ physiology
Conditioning, Classical
Craving
/ physiology
Cues
Glutamic Acid
/ physiology
Hypothalamic Area, Lateral
/ cytology
Mice
Midline Thalamic Nuclei
/ cytology
Neural Pathways
/ physiology
Neurons
/ physiology
Optogenetics
Patch-Clamp Techniques
Prefrontal Cortex
/ cytology
Reward
gamma-Aminobutyric Acid
/ physiology
behavioral optogenetics
drug addiction
feeding
lateral hypothalamus
learning
memory
midline thalamus
multiphoton calcium imaging
prelimbic cortex
sucrose seeking
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
07 08 2019
07 08 2019
Historique:
received:
20
11
2018
revised:
16
04
2019
accepted:
09
05
2019
pubmed:
15
6
2019
medline:
2
11
2019
entrez:
15
6
2019
Statut:
ppublish
Résumé
The paraventricular thalamus (PVT) is an interface for brain reward circuits, with input signals arising from structures, such as prefrontal cortex and hypothalamus, that are broadcast to downstream limbic targets. However, the precise synaptic connectivity, activity, and function of PVT circuitry for reward processing are unclear. Here, using in vivo two-photon calcium imaging, we find that PVT neurons projecting to the nucleus accumbens (PVT-NAc) develop inhibitory responses to reward-predictive cues coding for both cue-reward associative information and behavior. The multiplexed activity in PVT-NAc neurons is directed by opposing activity patterns in prefrontal and lateral hypothalamic afferent axons. Further, we find that prefrontal cue encoding may maintain accurate cue-reward processing, as optogenetic disruption of this encoding induced long-lasting effects on downstream PVT-NAc cue responses and behavioral cue discrimination. Together, these data reveal that PVT-NAc neurons act as an interface for reward processing by integrating relevant inputs to accurately inform reward-seeking behavior.
Identifiants
pubmed: 31196673
pii: S0896-6273(19)30443-X
doi: 10.1016/j.neuron.2019.05.018
pmc: PMC6773659
mid: NIHMS1531093
pii:
doi:
Substances chimiques
Glutamic Acid
3KX376GY7L
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
423-431.e4Subventions
Organisme : NINDS NIH HHS
ID : R01 NS090029
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS045892
Pays : United States
Organisme : NIDA NIH HHS
ID : F32 DA041184
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH060929
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS007431
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA038168
Pays : United States
Organisme : NIH HHS
ID : S10 OD021532
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD098657
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA032750
Pays : United States
Organisme : NIDA NIH HHS
ID : R37 DA032750
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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