Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury.
3-Hydroxybutyric Acid
/ therapeutic use
Animals
Fasting
Forkhead Box Protein O1
/ metabolism
Inflammation
/ drug therapy
Liver
/ metabolism
Liver Diseases
/ prevention & control
Male
Mice
Mice, Inbred C57BL
NF-kappa B
/ metabolism
NLR Family, Pyrin Domain-Containing 3 Protein
/ metabolism
Oxidative Stress
Reperfusion Injury
/ prevention & control
Up-Regulation
FOXO1
fasting
ischemia and reperfusion injury
β-hydroxybutyric acid
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
02 07 2019
02 07 2019
Historique:
pubmed:
15
6
2019
medline:
31
3
2020
entrez:
15
6
2019
Statut:
ppublish
Résumé
Liver ischemia and reperfusion injury (IRI) is a major challenge in liver surgery. Diet restriction reduces liver damage by increasing stress resistance; however, the underlying molecular mechanisms remain unclear. We investigated the preventive effect of 12-h fasting on mouse liver IRI. Partial warm hepatic IRI model in wild-type male C57BL/6 mice was used. The control ischemia and reperfusion (IR) group of mice was given food and water ad libitum, while the fasting IR group was given water but not food for 12 h before ischemic insult. In 12-h fasting mice, serum liver-derived enzyme level and tissue damages due to IR were strongly suppressed. Serum β-hydroxybutyric acid (BHB) was significantly raised before ischemia and during reperfusion. Up-regulated BHB induced an increment in the expression of FOXO1 transcription factor by raising the level of acetylated histone. Antioxidative enzyme heme oxigenase 1 (HO-1), a target gene of FOXO1, then increased. Autophagy activity was also enhanced. Serum high-mobility group box 1 was remarkably lowered by the 12-h fasting, and activation of NF-κB and NLRP3 inflammasome was suppressed. Consequently, inflammatory cytokine production and liver injury were reduced. Exogenous BHB administration or histone deacetylase inhibitor administration into the control fed mice ameliorated liver IRI, while FOXO1 inhibitor administration to the 12-h fasting group exacerbated liver IRI. The 12-h fasting exerted beneficial effects on the prevention of liver IRI by increasing BHB, thus up-regulating FOXO1 and HO-1, and by reducing the inflammatory responses and apoptotic cell death via the down-regulation of NF-κB and NLRP3 inflammasome.
Identifiants
pubmed: 31196960
pii: 1820282116
doi: 10.1073/pnas.1820282116
pmc: PMC6613133
doi:
Substances chimiques
Forkhead Box Protein O1
0
Foxo1 protein, mouse
0
NF-kappa B
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Nlrp3 protein, mouse
0
3-Hydroxybutyric Acid
TZP1275679
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13533-13542Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Annu Rev Immunol. 2000;18:621-63
pubmed: 10837071
J Hepatol. 2000 Aug;33(2):236-46
pubmed: 10952241
Am J Surg. 2001 Feb;181(2):160-6
pubmed: 11425059
Nat Immunol. 2001 Aug;2(8):675-80
pubmed: 11477402
Jpn J Pharmacol. 2002 May;89(1):36-43
pubmed: 12083741
Mol Cell Biochem. 2002 May-Jun;234-235(1-2):249-63
pubmed: 12162441
Nature. 2003 May 29;423(6939):550-5
pubmed: 12754525
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11285-90
pubmed: 13679577
Curr Med Chem. 2004 Jun;11(12):1629-43
pubmed: 15180568
J Exp Med. 2005 Apr 4;201(7):1135-43
pubmed: 15795240
Gut. 2005 Jun;54(6):835-42
pubmed: 15888794
Nat Rev Immunol. 2006 Apr;6(4):318-28
pubmed: 16557263
J Clin Invest. 2006 Sep;116(9):2464-72
pubmed: 16906224
Oncogene. 2006 Oct 30;25(51):6758-80
pubmed: 17072327
World J Gastroenterol. 2006 Nov 14;12(42):6812-7
pubmed: 17106930
Nat Rev Mol Cell Biol. 2007 Jan;8(1):49-62
pubmed: 17183360
Curr Biol. 2007 Oct 9;17(19):1646-56
pubmed: 17900900
Free Radic Biol Med. 1991;11(1):81-128
pubmed: 1937131
Hum Gene Ther. 2009 Oct;20(10):1133-42
pubmed: 19534599
Liver Transpl. 2009 Aug;15(8):939-47
pubmed: 19642132
J Biol Chem. 2009 Oct 9;284(41):28319-31
pubmed: 19696026
Nat Med. 2009 Oct;15(10):1170-8
pubmed: 19767732
Aging Cell. 2010 Feb;9(1):40-53
pubmed: 19878145
Hepatology. 2010 Apr;51(4):1363-72
pubmed: 20091883
Transplantation. 2010 May 15;89(9):1050-6
pubmed: 20160675
Nature. 2010 Mar 4;464(7285):104-7
pubmed: 20203610
Gastroenterology. 2010 Dec;139(6):2195-206
pubmed: 20637206
Surg Clin North Am. 2010 Aug;90(4):665-77
pubmed: 20637940
Mol Pharmacol. 2010 Nov;78(5):961-70
pubmed: 20736318
Hepatology. 2010 Oct;52(4):1380-9
pubmed: 20815020
Circ Res. 2010 Dec 10;107(12):1470-82
pubmed: 20947830
Biochim Biophys Acta. 2011 Nov;1813(11):1954-60
pubmed: 21396404
Cell. 2011 May 13;145(4):607-21
pubmed: 21565617
Liver Transpl. 2011 Jun;17(6):695-704
pubmed: 21618690
Gastroenterology. 2011 Dec;141(6):2188-2199.e6
pubmed: 21854730
Nat Med. 2011 Nov 07;17(11):1391-401
pubmed: 22064429
Science. 2013 Jan 11;339(6116):211-4
pubmed: 23223453
N Engl J Med. 2013 Feb 14;368(7):651-62
pubmed: 23406030
PLoS One. 2013 Nov 08;8(11):e80521
pubmed: 24255720
J Hepatol. 2014 Aug;61(2):301-8
pubmed: 24751831
Mol Med. 2014 Oct 14;20:448-55
pubmed: 25014792
Cell. 2015 Jan 15;160(1-2):132-44
pubmed: 25542313
Nat Med. 2015 Mar;21(3):263-9
pubmed: 25686106
Am J Transplant. 2015 Apr;15(4):965-73
pubmed: 25708614
Cell. 2015 Mar 26;161(1):106-118
pubmed: 25815989
J Immunol. 2015 May 1;194(9):4507-17
pubmed: 25825440
Neurobiol Aging. 2015 Jul;36(7):2296-2303
pubmed: 25896951
Autophagy. 2015 Apr 3;11(4):629-42
pubmed: 25919885
Liver Transpl. 2015 Jul;21(7):969-81
pubmed: 25931247
Oncotarget. 2016 Apr 5;7(14):17532-46
pubmed: 27007158
Am J Transplant. 2017 Jan;17(1):69-80
pubmed: 27467205
Am J Transl Res. 2016 Aug 15;8(8):3364-75
pubmed: 27648127
JCI Insight. 2016 Dec 8;1(20):e89679
pubmed: 27942590
Cell Metab. 2017 Jul 5;26(1):71-93
pubmed: 28683296
Nat Immunol. 2017 Jul 19;18(8):843-850
pubmed: 28722707
Am J Transplant. 2018 May;18(5):1110-1121
pubmed: 29136322
JPEN J Parenter Enteral Nutr. 2019 Jan;43(1):133-144
pubmed: 29870084
Lab Invest. 2018 Aug;98(8):1052-1064
pubmed: 29884910
Diabetes. 1971 Jul;20(7):485-9
pubmed: 4997333
Stroke. 1980 Sep-Oct;11(5):513-7
pubmed: 6775395
Transplantation. 1993 Jun;55(6):1265-72
pubmed: 7685932