Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts.
Animals
Antigen Presentation
/ immunology
Cancer-Associated Fibroblasts
/ immunology
Carcinoma, Pancreatic Ductal
/ etiology
Fluorescent Antibody Technique
Histocompatibility Antigens Class II
/ genetics
Humans
Mice
Models, Biological
Pancreatic Neoplasms
/ etiology
Single-Cell Analysis
Tumor Microenvironment
/ immunology
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
22
01
2019
revised:
18
04
2019
accepted:
30
05
2019
pubmed:
15
6
2019
medline:
6
8
2020
entrez:
15
6
2019
Statut:
ppublish
Résumé
Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell population consisting of several recently described subtypes, although the extent of CAF heterogeneity has remained undefined. Here we use single-cell RNA sequencing to thoroughly characterize the neoplastic and tumor microenvironment content of human and mouse PDAC tumors. We corroborate the presence of myofibroblastic CAFs and inflammatory CAFs and define their unique gene signatures
Identifiants
pubmed: 31197017
pii: 2159-8290.CD-19-0094
doi: 10.1158/2159-8290.CD-19-0094
pmc: PMC6727976
mid: NIHMS1531188
doi:
Substances chimiques
Histocompatibility Antigens Class II
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1102-1123Subventions
Organisme : NCI NIH HHS
ID : P20 CA192996
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA188134
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA209997
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA184926
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA190092
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA224013
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA101955
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIH HHS
ID : S10 OD012351
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA182076
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA045508
Pays : United States
Organisme : NIH HHS
ID : S10 OD021764
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA197296
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014195
Pays : United States
Organisme : NCI NIH HHS
ID : R33 CA206949
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA202762
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA204725
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211506
Pays : United States
Organisme : NCI NIH HHS
ID : P20 CA192994
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA034196
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NCI NIH HHS
ID : U10 CA180944
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA168409
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA210240
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA217858
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA148056
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197745
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
©2019 American Association for Cancer Research.
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