The purinergic receptor antagonist oxidized adenosine triphosphate suppresses immune-mediated corneal allograft rejection.

Adenosine Triphosphate / metabolism Allografts / drug effects Animals Antigen-Presenting Cells / drug effects CD4-Positive T-Lymphocytes / drug effects Cornea / drug effects Corneal Transplantation Graft Rejection / immunology Leukocytes / drug effects Lymphocyte Count Male Mice, Inbred BALB C Mice, Inbred C57BL Oxidation-Reduction Purinergic Antagonists / pharmacology Receptors, Purinergic / metabolism

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
13 06 2019
Historique:
received: 19 09 2018
accepted: 20 05 2019
entrez: 15 6 2019
pubmed: 15 6 2019
medline: 21 10 2020
Statut: epublish

Résumé

Adenosine triphosphate (ATP) is released into the extracellular environment during transplantation, and acts via purinergic receptors to amplify the alloimmune response. Here, using a well-established murine model of allogeneic corneal transplantation, we investigated the immunomodulatory mechanisms of the purinergic receptor antagonist oxidized ATP (oATP). Corneal transplantation was performed using C57BL/6 donors and BALB/c hosts. oATP or sterile saline was administered via intraperitoneal injection for 2 weeks postoperatively. Frequencies of CD45

Identifiants

DOI: 10.1038/s41598-019-44973-y PMID: 31197223 PMC: PMC6565802
pubmed: 31197223
doi: 10.1038/s41598-019-44973-y
pii: 10.1038/s41598-019-44973-y
pmc: PMC6565802
doi:

Substances chimiques

Purinergic Antagonists 0
Receptors, Purinergic 0
Adenosine Triphosphate 8L70Q75FXE

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

8617

Subventions

Organisme : NEI NIH HHS
ID : P30 EY003790
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY012963
Pays : United States

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Auteurs

William Foulsham (W)

Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Institute of Ophthalmology, University College London, London, UK.
ORCID: 0000-0002-7088-605X

Sharad K Mittal (SK)

Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Takeshi Nakao (T)

Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.

Giulia Coco (G)

Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.

Yukako Taketani (Y)

Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Sunil K Chauhan (SK)

Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Reza Dana (R)

Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA. reza_dana@meei.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Régions du corps › Transplants › Allogreffes › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Eucaryotes › Animaux › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Cellules présentatrices d'antigène › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Organes des sens › Oeil › Pôle antérieur du bulbe oculaire › Cornée › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation de tissu › Transplantation de cornée › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Rejet du greffon › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémogramme › Numération des leucocytes › Numération des lymphocytes › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Antagonistes purinergiques › The purinergic receptor antagonist oxidized...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › The purinergic receptor antagonist oxidized...