Outcomes of haploidentical vs matched sibling transplantation for acute myeloid leukemia in first complete remission.
Adolescent
Adult
Aged
Blood Donors
/ statistics & numerical data
Bone Marrow Transplantation
/ statistics & numerical data
Calcineurin Inhibitors
/ therapeutic use
Chronic Disease
Cyclophosphamide
/ therapeutic use
Disease-Free Survival
Female
Graft vs Host Disease
/ epidemiology
Hematopoietic Stem Cell Transplantation
/ methods
Humans
Immunosuppressive Agents
/ therapeutic use
Incidence
Leukemia, Myeloid, Acute
/ drug therapy
Male
Middle Aged
Recurrence
Remission Induction
Retrospective Studies
Siblings
Survival Analysis
Transplantation Conditioning
/ methods
Transplantation, Haploidentical
/ adverse effects
Young Adult
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
25 06 2019
25 06 2019
Historique:
received:
19
02
2019
accepted:
04
04
2019
entrez:
16
6
2019
pubmed:
16
6
2019
medline:
17
6
2020
Statut:
ppublish
Résumé
HLA-haploidentical hematopoietic cell transplantation (Haplo-HCT) using posttransplantation cyclophosphamide (PT-Cy) has improved donor availability. However, a matched sibling donor (MSD) is still considered the optimal donor. Using the Center for International Blood and Marrow Transplant Research database, we compared outcomes after Haplo-HCT vs MSD in patients with acute myeloid leukemia (AML) in first complete remission (CR1). Data from 1205 adult CR1 AML patients (2008-2015) were analyzed. A total of 336 patients underwent PT-Cy-based Haplo-HCT and 869 underwent MSD using calcineurin inhibitor-based graft-versus-host disease (GVHD) prophylaxis. The Haplo-HCT group included more reduced-intensity conditioning (65% vs 30%) and bone marrow grafts (62% vs 7%), consistent with current practice. In multivariable analysis, Haplo-HCT and MSD groups were not different with regard to overall survival (
Identifiants
pubmed: 31201170
pii: bloodadvances.2019000050
doi: 10.1182/bloodadvances.2019000050
pmc: PMC6595262
doi:
Substances chimiques
Calcineurin Inhibitors
0
Immunosuppressive Agents
0
Cyclophosphamide
8N3DW7272P
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1826-1836Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL069294
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA076518
Pays : United States
Références
Am J Hematol. 2018 Oct;93(10):1236-1244
pubmed: 30058714
Blood. 2016 Feb 18;127(7):938-47
pubmed: 26670632
Stat Med. 1999 Jun 30;18(12):1489-500
pubmed: 10398287
J Clin Oncol. 2017 Oct 20;35(30):3425-3432
pubmed: 28846465
Biol Blood Marrow Transplant. 2015 Jan;21(1):4-7
pubmed: 25278457
Haematologica. 2018 Aug;103(8):1317-1328
pubmed: 29748438
J Clin Oncol. 2016 Sep 10;34(26):3141-9
pubmed: 27269951
Biol Blood Marrow Transplant. 2016 Jun;22(6):1024-1029
pubmed: 26903380
N Engl J Med. 2016 Sep 8;375(10):944-53
pubmed: 27602666
J Hematol Oncol. 2018 Aug 30;11(1):110
pubmed: 30165887
Haematologica. 2016 Aug;101(8):e352-4
pubmed: 27081180
JAMA Oncol. 2016 Dec 1;2(12):1583-1589
pubmed: 27532508
Bone Marrow Transplant. 2006 Aug;38(4):305-10
pubmed: 16819438
Cancer. 2015 Jun 1;121(11):1809-16
pubmed: 25649994
Biol Blood Marrow Transplant. 2016 Sep;22(9):1696-1701
pubmed: 27223108
Blood. 2005 Oct 15;106(8):2912-9
pubmed: 15994282
J Clin Oncol. 2015 Oct 1;33(28):3152-61
pubmed: 26261255
Br J Haematol. 2000 Sep;110(3):614-9
pubmed: 10997973
Blood. 2011 Mar 17;117(11):3214-9
pubmed: 21263156
Blood Adv. 2018 Jun 12;2(11):1180-1186
pubmed: 29794073
Blood Adv. 2018 Feb 13;2(3):299-307
pubmed: 29440002
N Engl J Med. 2012 Oct 18;367(16):1487-96
pubmed: 23075175
Blood. 2010 Nov 25;116(22):4693-9
pubmed: 20686119
J Clin Oncol. 2017 Sep 10;35(26):3002-3009
pubmed: 28644773
J Clin Oncol. 2016 Feb 1;34(4):329-36
pubmed: 26668349
Blood. 2015 Aug 20;126(8):1033-40
pubmed: 26130705
J Clin Oncol. 1997 May;15(5):1767-77
pubmed: 9164184
Blood. 2016 Mar 17;127(11):1502-8
pubmed: 26764356
Bone Marrow Transplant. 2019 Sep;54(9):1499-1510
pubmed: 30718798
Blood. 2000 Dec 15;96(13):4075-83
pubmed: 11110676