Bisphenol S alters development of the male mouse mammary gland and sensitizes it to a peripubertal estrogen challenge.
Animals
Animals, Newborn
Dose-Response Relationship, Drug
Endocrine Disruptors
/ toxicity
Estrogens
/ toxicity
Female
Genitalia
/ drug effects
Male
Mammary Glands, Animal
/ drug effects
Mice
Organ Size
/ drug effects
Phenols
/ toxicity
Pregnancy
Prenatal Exposure Delayed Effects
/ metabolism
Receptors, Estrogen
/ drug effects
Seminal Vesicles
/ drug effects
Sexual Maturation
Sulfones
/ toxicity
4,4′-sulfonyldiphenol
Bisphenol S
Endocrine disruptor
Estrogen receptor
Mammary epithelium
Nipple retention
Two hit model
Journal
Toxicology
ISSN: 1879-3185
Titre abrégé: Toxicology
Pays: Ireland
ID NLM: 0361055
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
received:
28
12
2018
revised:
22
05
2019
accepted:
11
06
2019
pubmed:
16
6
2019
medline:
15
5
2020
entrez:
16
6
2019
Statut:
ppublish
Résumé
Humans are exposed to estrogenic chemicals in food and food packaging, personal care products, and other industrial and consumer goods. Bisphenol A (BPA), a well-studied xenoestrogen, is known to alter development of estrogen-sensitive organs including the brain, reproductive tract, and mammary gland. Bisphenol S (BPS; 4,4'-sulfonyldiphenol), which has a similar chemical structure to BPA, is also used in many consumer products, but its effects on estrogen-sensitive organs in mammals has not been thoroughly examined. Here, we quantified the effects of perinatal exposures to BPS on the male mouse mammary gland. In our first study, pregnant CD-1 mice were orally exposed to BPS (2 or 200 μg/kg/day) starting on pregnancy day 9 through lactation day 20, and male mammary glands were evaluated on embryonic day 16, prior to puberty, and in early adulthood. We observed modest changes in tissue organization in the fetal gland, and significant increases in growth of the gland induced by developmental BPS exposure in adulthood. In our second study, pregnant CD-1 mice were orally exposed to BPS (2, 200 or 2000 μg/kg/day) starting on pregnancy day 9 through lactational day 2. After weaning, the male pups were administered either oil (vehicle) or an estrogen challenge (1 μg ethinyl estradiol/kg/day) for ten days starting prior to puberty. After the 10-day estrogen challenge, we examined hormone-sensitive outcomes including anogenital index (AGI), weight of the seminal vesicles, and morphological parameters of the mammary gland. Although AGI and seminal vesicle weight were not affected by BPS, we observed dose-specific effects on the response of male mammary glands to the peripubertal estrogen challenge. Because male mammary glands are structurally less developed compared to females, they may provide a simple model tissue to evaluate the effects of putative xenoestrogens.
Identifiants
pubmed: 31201878
pii: S0300-483X(18)30761-3
doi: 10.1016/j.tox.2019.06.005
pmc: PMC6736534
mid: NIHMS1532604
pii:
doi:
Substances chimiques
Endocrine Disruptors
0
Estrogens
0
Phenols
0
Receptors, Estrogen
0
Sulfones
0
bis(4-hydroxyphenyl)sulfone
80-09-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
152234Subventions
Organisme : NIEHS NIH HHS
ID : K22 ES025811
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Références
J Mammary Gland Biol Neoplasia. 1999 Jan;4(1):9-19
pubmed: 10219903
Proc Natl Acad Sci U S A. 1976 Nov;73(11):4041-4
pubmed: 1069291
Hum Reprod Update. 2001 May-Jun;7(3):248-64
pubmed: 11392371
Biol Reprod. 2001 Oct;65(4):1215-23
pubmed: 11566746
Toxicol Pathol. 2002 Jan-Feb;30(1):59-65
pubmed: 11892727
Toxicol Sci. 2002 Jul;68(1):121-46
pubmed: 12075117
Endocrinology. 2005 Sep;146(9):4138-47
pubmed: 15919749
Cancer Res. 2006 Jun 1;66(11):5624-32
pubmed: 16740699
Endocrinology. 2007 Jan;148(1):116-27
pubmed: 17023525
Reprod Toxicol. 2007 Apr-May;23(3):374-82
pubmed: 17123779
N Engl J Med. 2007 Feb 1;356(5):479-85
pubmed: 17267908
J Androl. 2007 Jul-Aug;28(4):513-20
pubmed: 17287459
Environ Health Perspect. 2007 Apr;115(4):592-8
pubmed: 17450229
Environ Health Perspect. 2007 Dec;115 Suppl 1:122-8
pubmed: 18174960
Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):134-8
pubmed: 18226066
Fertil Steril. 2008 Feb;89(2 Suppl):e41
pubmed: 18308059
J Clin Invest. 2008 Apr;118(4):1479-90
pubmed: 18340380
Toxicol Sci. 2008 Aug;104(2):362-84
pubmed: 18445619
Environ Health Perspect. 2009 Dec;117(12):1839-46
pubmed: 20049201
J Pediatr Surg. 2010 Mar;45(3):650-4
pubmed: 20223338
Reprod Toxicol. 2010 Sep;30(2):313-21
pubmed: 20420898
Reprod Toxicol. 2011 Jan;31(1):1-9
pubmed: 20887781
Reprod Toxicol. 2011 Feb;31(2):200-9
pubmed: 21075200
Birth Defects Res B Dev Reprod Toxicol. 2010 Dec;89(6):441-66
pubmed: 21136531
Environ Toxicol Pharmacol. 2005 Jan;19(1):121-30
pubmed: 21783468
Environ Sci Technol. 2012 Jun 19;46(12):6515-22
pubmed: 22591511
Environ Sci Technol. 2012 Jun 19;46(12):6860-6
pubmed: 22620267
Environ Sci Technol. 2012 Aug 21;46(16):9138-45
pubmed: 22784190
Wiley Interdiscip Rev Dev Biol. 2012 Jul-Aug;1(4):533-57
pubmed: 22844349
Reprod Toxicol. 2013 Jun;37:15-23
pubmed: 23348055
J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):43-61
pubmed: 23417729
J Agric Food Chem. 2013 May 15;61(19):4655-62
pubmed: 23614805
PLoS One. 2013 May 21;8(5):e63902
pubmed: 23704952
Birth Defects Res B Dev Reprod Toxicol. 2014 Feb;101(1):43-62
pubmed: 24510766
Toxicol Sci. 2014 May;139(1):35-47
pubmed: 24563381
Environ Health Perspect. 2015 Jul;123(7):643-50
pubmed: 25775505
Environ Health. 2015 Aug 05;14:64
pubmed: 26242739
Environ Sci Technol. 2015 Oct 6;49(19):11834-9
pubmed: 26360019
Ecotoxicol Environ Saf. 2015 Dec;122:565-72
pubmed: 26436777
Prog Clin Biol Res. 1989;302:193-206; discussion 206-9
pubmed: 2666989
Andrology. 2016 Jul;4(4):673-83
pubmed: 27088260
Toxicology. 2016 Aug 10;368-369:152-161
pubmed: 27639664
Methods Mol Biol. 2017;1501:21-76
pubmed: 27796947
Environ Health. 2017 Mar 9;16(1):25
pubmed: 28279175
J Breast Health. 2015 Jul 01;11(3):106-110
pubmed: 28331703
Environ Sci Technol. 2017 May 2;51(9):5279-5286
pubmed: 28368574
Cell Death Differ. 2017 Jun;24(6):1029-1044
pubmed: 28475176
Endocrinology. 2017 Oct 1;158(10):3448-3461
pubmed: 28977596
Reprod Toxicol. 2018 Jun;78:50-59
pubmed: 29526645
Mol Cell Endocrinol. 2018 Nov 5;475:29-53
pubmed: 30048677
Environ Health Perspect. 2018 Aug 10;126(8):087003
pubmed: 30102602
Reprod Toxicol. 2018 Dec;82:63-71
pubmed: 30315872
Environ Health Perspect. 2018 Nov;126(11):117001
pubmed: 30387366
Arch Toxicol. 2019 Feb;93(2):253-272
pubmed: 30430187
Nat Rev Endocrinol. 2019 Jun;15(6):366-374
pubmed: 30842650
Cogent Med. 2017;4(1):null
pubmed: 31231671
Data Brief. 2019 Mar 20;25:103862
pubmed: 31245508
J Embryol Exp Morphol. 1971 Feb;25(1):141-53
pubmed: 5548210
Dev Biol. 1977 Dec;61(2):358-65
pubmed: 590632