Successful treatment and digestive decolonisation of a patient with osteitis caused by a carbapenemase-producing Klebsiella pneumoniae isolate harbouring both NDM-1 and OXA-48 enzymes.
Adult
Anti-Bacterial Agents
/ pharmacology
Bacterial Proteins
/ adverse effects
Carbapenems
/ therapeutic use
Drug Resistance, Multiple, Bacterial
/ drug effects
Fecal Microbiota Transplantation
/ methods
Humans
Klebsiella pneumoniae
/ enzymology
Male
Microbial Sensitivity Tests
Osteitis
/ chemically induced
Plasmids
/ genetics
Whole Genome Sequencing
beta-Lactamases
/ adverse effects
Carbapenem-resistant Enterobacteriaceae
Klebsiella pneumoniae
New Delhi metallo-β-lactamase (NDM-1)
OXA-48
Osteitis
Journal
Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
30
01
2019
revised:
20
05
2019
accepted:
03
06
2019
pubmed:
16
6
2019
medline:
23
6
2020
entrez:
16
6
2019
Statut:
ppublish
Résumé
Carbapenem resistance in Klebsiella pneumoniae is an increasing problem worldwide and infections caused by this bacterium can be difficult to treat. This study reported the case of a patient from Romania, who was hospitalised in Bulgaria after an accident trauma. He then came to France for treatment of an osteitis caused by a Klebsiella pneumoniae carrying both bla The resistome of this extremely drug-resistant bacterium was analysed both with phenotypic (large antibiotic susceptibility testing) and genomic methods (genome sequencing). The genetic environment of the two carbapenemases was studied. Klebsiella pneumoniae ST307 carrying both a bla The ST307 type is becoming endemic in hospital environments and is frequently associated with carbapenem resistance. Treatment of infection caused by multidrug-resistant bacteria is a clinical challenge, and the use of old antibiotics associated with screening and decolonisation of the reservoirs can be an efficient therapeutic alternative.
Identifiants
pubmed: 31201994
pii: S2213-7165(19)30144-4
doi: 10.1016/j.jgar.2019.06.001
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Carbapenems
0
beta-Lactamases
EC 3.5.2.6
beta-lactamase NDM-1
EC 3.5.2.6
carbapenemase
EC 3.5.2.6
oxacillinase
EC 3.5.2.6
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
225-229Informations de copyright
Copyright © 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd. All rights reserved.