Effects of vildagliptin, a DPP-4 inhibitor, in elderly diabetic patients with mild cognitive impairment.
Aged
Aged, 80 and over
Cognitive Dysfunction
/ drug therapy
Diabetes Mellitus, Type 2
/ drug therapy
Dipeptidyl-Peptidase IV Inhibitors
/ therapeutic use
Female
Glycated Hemoglobin
/ analysis
Humans
Hypoglycemic Agents
/ therapeutic use
Male
Mental Status and Dementia Tests
Metformin
/ therapeutic use
Retrospective Studies
Vildagliptin
/ therapeutic use
DPP-4 inhibitors
Diabetes mellitus
Elderly
Mild Cognitive Impairment
Vildagliptin
Journal
Archives of gerontology and geriatrics
ISSN: 1872-6976
Titre abrégé: Arch Gerontol Geriatr
Pays: Netherlands
ID NLM: 8214379
Informations de publication
Date de publication:
Historique:
received:
13
04
2019
revised:
02
06
2019
accepted:
02
06
2019
pubmed:
18
6
2019
medline:
20
3
2020
entrez:
18
6
2019
Statut:
ppublish
Résumé
There is an unclear association between type 2 diabetes and mild cognitive impairment in the elderly. Both diseases are more prevalent in the older adults compared to the younger counterpart. Some anti-diabetic drugs seem to influence positively the evolution of mild cognitive impairment. This retrospective study investigated the effect of vildagliptin, an inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4), on the cognitive functioning of elderly diabetic patients with mild cognitive impairment (MCI) documented at mini mental state examination (MMSE). We included 60 diabetic elderly people which were divided in 2 groups: Group A, 30 patients with HbA The two groups exhibited significantly different values in FPG (P < 0.05) and HbA Vildagliptin in addition to metformin resulted in the maintenance of MMSE score, showing a protecting role on cognitive functioning compared to the metformin only group.
Identifiants
pubmed: 31204117
pii: S0167-4943(19)30139-6
doi: 10.1016/j.archger.2019.06.001
pii:
doi:
Substances chimiques
Dipeptidyl-Peptidase IV Inhibitors
0
Glycated Hemoglobin A
0
Hypoglycemic Agents
0
hemoglobin A1c protein, human
0
Metformin
9100L32L2N
Vildagliptin
I6B4B2U96P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103896Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.