TOX is a critical regulator of tumour-specific T cell differentiation.
Animals
CD8-Positive T-Lymphocytes
/ cytology
Cell Differentiation
/ immunology
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
High Mobility Group Proteins
/ deficiency
Homeodomain Proteins
/ genetics
Humans
Immunologic Memory
Lymphocytes, Tumor-Infiltrating
/ cytology
Mice
Neoplasms
/ immunology
Phenotype
Receptors, Antigen, T-Cell
/ immunology
Transcription, Genetic
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
18
05
2018
accepted:
04
06
2019
pubmed:
18
6
2019
medline:
1
10
2019
entrez:
18
6
2019
Statut:
ppublish
Résumé
Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the functional effector or memory T cell states
Identifiants
pubmed: 31207604
doi: 10.1038/s41586-019-1324-y
pii: 10.1038/s41586-019-1324-y
pmc: PMC7698992
mid: NIHMS1531023
doi:
Substances chimiques
High Mobility Group Proteins
0
Homeodomain Proteins
0
Receptors, Antigen, T-Cell
0
Rhox8 protein, mouse
0
TOX protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
270-274Subventions
Organisme : NIAID NIH HHS
ID : R01 AI054977
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA158069
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA172371
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR070234
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA209975
Pays : United States
Organisme : NCI NIH HHS
ID : DP2 CA225212
Pays : United States
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