Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways.
IGF1 receptor (IGF1R)
Laron syndrome
cancer protection
growth hormone receptor (GH-R)
insulin-like growth factor 1 (IGF1)
thioredoxin-interacting protein (TXNIP)
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
15 06 2019
15 06 2019
Historique:
received:
11
05
2019
revised:
12
06
2019
accepted:
14
06
2019
entrez:
19
6
2019
pubmed:
19
6
2019
medline:
19
6
2019
Statut:
epublish
Résumé
Laron syndrome (LS), or primary growth hormone resistance, is a prototypical congenital insulin-like growth factor 1 (IGF1) deficiency. The recent epidemiological finding that LS patients do not develop cancer is of major scientific and clinical relevance. Epidemiological data suggest that congenital IGF1 deficiency confers protection against the development of malignancies. This 'experiment of nature' reflects the critical role of IGF1 in tumor biology. The present review article provides an overview of recently conducted genome-wide profiling analyses aimed at identifying mechanisms and signaling pathways that are directly responsible for the link between life-time low IGF1 levels and protection from tumor development. The review underscores the concept that 'data mining' an orphan disease might translate into new developments in oncology.
Identifiants
pubmed: 31208077
pii: cells8060596
doi: 10.3390/cells8060596
pmc: PMC6627189
pii:
doi:
Substances chimiques
IGF1 protein, human
0
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Science. 1998 Jan 23;279(5350):563-6
pubmed: 9438850
Growth Horm IGF Res. 2018 Feb;38:14-18
pubmed: 29277338
Endocr Pract. 2015 Dec;21(12):1395-402
pubmed: 26401581
Mol Genet Metab. 2000 Sep-Oct;71(1-2):315-20
pubmed: 11001824
Front Endocrinol (Lausanne). 2017 Jun 29;8:148
pubmed: 28706506
Isr Med Assoc J. 2017 Jan;19(1):6-7
pubmed: 28457105
Horm Res. 2006;65 Suppl 1:15-20
pubmed: 16508329
Endocrinol Metab Clin North Am. 2012 Jun;41(2):231-47, v
pubmed: 22682628
J Clin Endocrinol Metab. 1998 Feb;83(2):531-7
pubmed: 9467570
J Clin Endocrinol Metab. 2008 Nov;93(11):4210-7
pubmed: 18782877
Growth Horm IGF Res. 2016 Jun;28:43-5
pubmed: 26654694
Isr J Med Sci. 1966 Mar-Apr;2(2):152-5
pubmed: 5916640
Lancet Oncol. 2011 Aug;12(8):785-94
pubmed: 21782509
Am J Med Genet A. 2014 May;164A(5):1204-8
pubmed: 24664892
Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):302-10
pubmed: 17315038
Endocr Relat Cancer. 2016 May;23(5):399-410
pubmed: 27090428
J Clin Endocrinol Metab. 2006 Nov;91(11):4235-6
pubmed: 16954153
Mutat Res Rev Mutat Res. 2017 Apr - Jun;772:123-133
pubmed: 28528685
Endocr Connect. 2017 Aug;6(6):395-403
pubmed: 28649085
Hum Mutat. 1992;1(1):24-32
pubmed: 1284474
Endocr Dev. 2012;23:30-41
pubmed: 23182818
Growth Horm IGF Res. 2006 Feb;16(1):61-4
pubmed: 16442822
Expert Opin Ther Targets. 2009 Oct;13(10):1179-92
pubmed: 19663648
Pediatr Endocrinol Rev. 2015 Dec;13(2):521-30
pubmed: 26841640
J Biol Chem. 2014 Mar 21;289(12):8106-20
pubmed: 24482226
J Clin Endocrinol Metab. 2010 May;95(5):2316-24
pubmed: 20357178
N Engl J Med. 2003 Dec 4;349(23):2211-22
pubmed: 14657428
Growth Horm IGF Res. 2018 Feb;38:19-23
pubmed: 29249625
Oncogene. 2007 Mar 15;26(12):1811-9
pubmed: 16983336
J Pediatr Endocrinol Metab. 2002 Jul-Aug;15(7):1039-40
pubmed: 12199333
Cell. 2009 Jun 12;137(6):1001-4
pubmed: 19524504
Endocrinology. 2005 Dec;146(12):5188-96
pubmed: 16141391
Arch Physiol Biochem. 2008 Feb;114(1):17-22
pubmed: 18465355
EMBO J. 1994 Mar 15;13(6):1386-95
pubmed: 8137822
J Clin Endocrinol Metab. 1999 Dec;84(12):4436-43
pubmed: 10599699
Endocr Rev. 2001 Feb;22(1):53-74
pubmed: 11159816
BMC Cancer. 2013 Nov 22;13:556
pubmed: 24267955
Growth Horm IGF Res. 2016 Jun;28:46-50
pubmed: 26276451
NPJ Precis Oncol. 2017;1:
pubmed: 29152592
Novartis Found Symp. 2004;262:84-98; discussion 98-107, 265-8
pubmed: 15562824
Mol Cell Proteomics. 2005 Sep;4(9):1273-83
pubmed: 15958393
Growth Horm IGF Res. 2018 Apr;39:6-12
pubmed: 29208357
Carcinogenesis. 2011 Jul;32(7):955-63
pubmed: 21317301
Growth Horm IGF Res. 2008 Jun;18(3):198-204
pubmed: 17928251
Proteomics. 2005 Nov;5(16):4145-51
pubmed: 16196087
Nat Rev Cancer. 2012 Feb 16;12(3):159-69
pubmed: 22337149
N Engl J Med. 2003 Dec 4;349(23):2184-6
pubmed: 14657423
Nat Genet. 1997 May;16(1):13-4
pubmed: 9140387
Lancet. 1998 May 9;351(9113):1393-6
pubmed: 9593409
Cancer Treat Rev. 2014 Oct;40(9):1096-105
pubmed: 25123819
J Clin Endocrinol Metab. 2004 Mar;89(3):1031-44
pubmed: 15001582
Horm Res. 2006;65 Suppl 1:3-8
pubmed: 16508327
Pediatr Endocrinol Rev. 2018 Sep;16(Suppl 1):39-62
pubmed: 30378782
Pediatr Endocrinol Rev. 2009 Sep;7(1):2-5
pubmed: 19696710
J Clin Endocrinol Metab. 2007 Jun;92(6):2223-31
pubmed: 17405847
Proc Natl Acad Sci U S A. 1989 Oct;86(20):8083-7
pubmed: 2813379
Pediatr Endocrinol Rev. 2006 Aug;3 Suppl 3:489-97
pubmed: 17551471
Trends Endocrinol Metab. 2008 Aug;19(6):197-205
pubmed: 18515143
Eur J Endocrinol. 2011 Apr;164(4):485-9
pubmed: 21292919
Biochim Biophys Acta. 1994 Sep 13;1219(1):26-32
pubmed: 8086474
Lancet. 2004 Apr 24;363(9418):1346-53
pubmed: 15110491
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1045-1050
pubmed: 29339473
Nat Rev Cancer. 2014 May;14(5):329-41
pubmed: 24722429
J Biol Chem. 2006 Aug 4;281(31):21884-91
pubmed: 16766796
Cancer Res. 2008 May 15;68(10):3680-8
pubmed: 18483250
Oncotarget. 2017 Jun 1;8(37):60826-60840
pubmed: 28977828
N Engl J Med. 1996 Oct 31;335(18):1363-7
pubmed: 8857020
World Rev Nutr Diet. 2018;117:1-14
pubmed: 29393111
Breast Cancer Res Treat. 2010 Jun;121(3):661-9
pubmed: 19888649
Breast Cancer Res Treat. 1998 Feb;47(3):283-93
pubmed: 9516082
J Clin Endocrinol Metab. 2005 May;90(5):2855-64
pubmed: 15769976
Oncogene. 2012 May 31;31(22):2703-14
pubmed: 21963847
Ann Intern Med. 2008 Oct 7;149(7):461-71, W83-8
pubmed: 18838726
Sci Transl Med. 2011 Feb 16;3(70):70ra13
pubmed: 21325617
Growth Horm IGF Res. 2007 Feb;17(1):54-7
pubmed: 17166755
J Neurosci. 2011 Apr 20;31(16):6019-27
pubmed: 21508227
Mol Cell. 2013 Mar 28;49(6):1167-75
pubmed: 23453806
Aging Cell. 2018 Dec;17(6):e12836
pubmed: 30168649
Cancer Res. 2003 Jan 15;63(2):432-40
pubmed: 12543799
Hum Genet. 2007 Aug;122(1):1-21
pubmed: 17534663
Am J Respir Cell Mol Biol. 2009 Aug;41(2):179-88
pubmed: 19131643
Biochem Pharmacol. 2018 Oct;156:32-42
pubmed: 30086285
EMBO Mol Med. 2017 Oct;9(10):1338-1345
pubmed: 28801361
J Pediatr Endocrinol Metab. 1999 Apr;12 Suppl 1:231-49
pubmed: 10698588
Int J Cancer. 2003 Dec 20;107(6):873-7
pubmed: 14601044
Br J Cancer. 1998 Aug;78(4):515-20
pubmed: 9716037
J Clin Endocrinol Metab. 2008 Mar;93(3):1030-7
pubmed: 18073295
N Engl J Med. 2004 Feb 5;350(6):570-7
pubmed: 14762184