Altered Stool Microbiota of Infants with Cystic Fibrosis Shows a Reduction in Genera Associated with Immune Programming from Birth.
cystic fibrosis
cytokine
exacerbation
infant
intestine
microbiota
stool
Journal
Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
received:
15
04
2019
accepted:
24
05
2019
pubmed:
19
6
2019
medline:
5
6
2020
entrez:
19
6
2019
Statut:
epublish
Résumé
Previous work from our group indicated an association between the gastrointestinal microbiota of infants with cystic fibrosis (CF) and airway disease in this population. Here we report that stool microbiota of infants with CF demonstrates an altered but largely unchanging within-individual bacterial diversity (alpha diversity) over the first year of life, in contrast to the infants without CF (control cohort), which showed the expected increase in alpha diversity over the first year. The beta diversity, or between-sample diversity, of these two cohorts was significantly different over the first year of life and was statistically significantly associated with airway exacerbations, confirming our earlier findings. Compared with control infants, infants with CF had reduced levels of
Identifiants
pubmed: 31209076
pii: JB.00274-19
doi: 10.1128/JB.00274-19
pmc: PMC6657602
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R37 AI083256
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023275
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES007373
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023108
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK117469
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103413
Pays : United States
Organisme : NIEHS NIH HHS
ID : P01 ES022832
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL128192
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL134598
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007363
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM104416
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
Références
Am J Clin Nutr. 2001 Feb;73(2 Suppl):444S-450S
pubmed: 11157355
Clin Exp Immunol. 2001 Mar;123(3):421-7
pubmed: 11298129
Clin Microbiol Rev. 2002 Apr;15(2):194-222
pubmed: 11932230
Br Med Bull. 1992 Oct;48(4):912-30
pubmed: 1281036
J Pediatr. 1961 Oct;59:512-21
pubmed: 14449575
Eur Respir J. 2004 Jan;23(1):146-58
pubmed: 14738247
J Pediatr Gastroenterol Nutr. 2007 May;44(5):577-82
pubmed: 17460489
Clin Exp Allergy. 2010 May;40(5):811-9
pubmed: 20067483
Bioinformatics. 2011 Feb 15;27(4):592-3
pubmed: 21169378
Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2108-13
pubmed: 22308390
J Cyst Fibros. 2012 Sep;11(5):454-5
pubmed: 22538067
Bioinformatics. 2012 Aug 15;28(16):2106-13
pubmed: 22711789
J Bacteriol. 2012 Sep;194(17):4709-17
pubmed: 22753064
MBio. 2012 Aug 21;3(4):null
pubmed: 22911969
PLoS One. 2013 Apr 22;8(4):e61217
pubmed: 23630581
Environ Res. 2013 Oct;126:24-30
pubmed: 23769261
Environ Health. 2013 Jul 16;12:58
pubmed: 23866971
Clin Infect Dis. 2014 Feb;58(3):396-9
pubmed: 24178246
Nucleic Acids Res. 2014 Jan;42(Database issue):D643-8
pubmed: 24293649
J Cyst Fibros. 2014 May;13(3):311-8
pubmed: 24332997
Microbiome. 2013 Nov 01;1(1):27
pubmed: 24451123
J Pediatr Surg. 2014 Feb;49(2):280-3
pubmed: 24528967
Curr Opin Immunol. 2014 Feb;26:41-8
pubmed: 24556399
PLoS One. 2014 Feb 19;9(2):e87796
pubmed: 24586292
Ann Am Thorac Soc. 2014 Apr;11 Suppl 3:S161-8
pubmed: 24754825
Microbiome. 2014 Apr 28;2:14
pubmed: 25071935
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5096-104
pubmed: 25385629
Nutrients. 2014 Dec 24;7(1):45-73
pubmed: 25545102
PLoS One. 2015 Feb 06;10(2):e0116967
pubmed: 25658710
J Cyst Fibros. 2015 Mar;14(2):169-77
pubmed: 25677689
J Pediatr Gastroenterol Nutr. 2015 Sep;61(3):355-60
pubmed: 25782658
J Pediatr. 2015 Jul;167(1):138-47.e1-3
pubmed: 25818499
Dev Period Med. 2015 Jan-Mar;19(1):32-40
pubmed: 26003068
Nutr Clin Pract. 2015 Aug;30(4):488-500
pubmed: 26113561
JAMA Pediatr. 2016 Mar;170(3):212-9
pubmed: 26752321
Neonatology. 2016;109(4):239-47
pubmed: 26859305
Environ Health Perspect. 2016 Aug;124(8):1299-307
pubmed: 26955061
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
Paediatr Respir Rev. 2016 Aug;20 Suppl:6-7
pubmed: 27349725
Minerva Med. 2016 Dec;107(6):427-436
pubmed: 27425634
Eur J Pediatr. 2016 Oct;175(10):1255-66
pubmed: 27576473
Pediatr Pulmonol. 2016 Oct;51(S44):S35-S44
pubmed: 27662102
J Cyst Fibros. 2017 Mar;16(2):186-197
pubmed: 27693010
Cell Mol Life Sci. 2017 Jan;74(1):129-140
pubmed: 27709245
FEMS Microbiol Ecol. 2017 Feb;93(2):
pubmed: 27810876
Crit Rev Microbiol. 2017 Nov;43(6):690-708
pubmed: 28340310
J Cyst Fibros. 2017 Nov;16 Suppl 2:S14-S23
pubmed: 28986022
Microbiol Mol Biol Rev. 2017 Nov 8;81(4):
pubmed: 29118049
Front Microbiol. 2017 Oct 25;8:2100
pubmed: 29118752
Clin Nutr ESPEN. 2017 Apr;18:37-43
pubmed: 29132736
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1605-1610
pubmed: 29378945
Nutrients. 2018 Feb 28;10(3):null
pubmed: 29495552
PLoS One. 2018 Jun 22;13(6):e0198457
pubmed: 29933382
J Clin Med. 2019 May 10;8(5):null
pubmed: 31083321
J Cyst Fibros. 2019 May 21;:null
pubmed: 31126900
Biotechnology (N Y). 1993 Oct;11(10):1133-6
pubmed: 7764093
Am J Physiol. 1995 May;268(5 Pt 2):F854-61
pubmed: 7771514