Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK.

Acetates / metabolism Acetyl-CoA Carboxylase / antagonists & inhibitors Autophagy / drug effects Lipogenesis Macrolides / pharmacology Mutagenesis, Site-Directed Protein Serine-Threonine Kinases / metabolism Saccharomyces cerevisiae / metabolism Saccharomyces cerevisiae Proteins / antagonists & inhibitors
AMPK Acc1 Snf1 acetate acetyl coenzyme A (acetyl-CoA) acetyl-CoA carboxylase 1 aging autophagy lipid metabolism lipogenesis oleate yeast

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
09 08 2019
Historique:
received: 05 12 2018
revised: 31 05 2019
pubmed: 19 6 2019
medline: 17 3 2020
entrez: 19 6 2019
Statut: ppublish

Résumé

Autophagy, a membrane-dependent catabolic process, ensures survival of aging cells and depends on the cellular energetic status. Acetyl-CoA carboxylase 1 (Acc1) connects central energy metabolism to lipid biosynthesis and is rate-limiting for the

Identifiants

DOI: 10.1074/jbc.RA118.007020 PMID: 31209110 PMC: PMC6690696
pubmed: 31209110
pii: S0021-9258(20)30154-X
doi: 10.1074/jbc.RA118.007020
pmc: PMC6690696
pii:
doi:

Substances chimiques

Acetates 0
Macrolides 0
Saccharomyces cerevisiae Proteins 0
soraphen A 122547-72-2
SNF1-related protein kinases EC 2.7.1.-
Protein Serine-Threonine Kinases EC 2.7.11.1
Acetyl-CoA Carboxylase EC 6.4.1.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12020-12039

Subventions

Organisme : Austrian Science Fund FWF
ID : I 3792
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 27183
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 28854
Pays : Austria

Informations de copyright

© 2019 Gross et al.

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Auteurs

Angelina S Gross (AS)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Andreas Zimmermann (A)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria; Central Lab Gracia, NAWI Graz, University of Graz, 8010 Graz, Austria.

Tobias Pendl (T)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Sabrina Schroeder (S)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria; BioTechMed-Graz, 8010 Graz, Austria.

Hannes Schoenlechner (H)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Oskar Knittelfelder (O)

Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

Laura Lamplmayr (L)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Ana Santiso (A)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Andreas Aufschnaiter (A)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria; Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, 114 19 Stockholm, Sweden.

Daniel Waltenstorfer (D)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Sandra Ortonobes Lara (S)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Sarah Stryeck (S)

Gottfried Schatz Research Center for Cell Signaling, Metabolism, and Aging, Institute of Molecular Biology and Biochemistry, Medical University of Graz, 8036 Graz, Austria.

Christina Kast (C)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Christoph Ruckenstuhl (C)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Sebastian J Hofer (SJ)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria; BioTechMed-Graz, 8010 Graz, Austria.

Birgit Michelitsch (B)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria; Division of Plastic, Aesthetic, and Reconstructive Surgery, Department of Surgery, Medical University of Graz, 8036 Graz, Austria.

Martina Woelflingseder (M)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Rolf Müller (R)

Helmholtz Institute for Pharmaceutical Research Saarland, 66123 Saarbrücken, Germany.

Didac Carmona-Gutierrez (D)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Tobias Madl (T)

BioTechMed-Graz, 8010 Graz, Austria; Gottfried Schatz Research Center for Cell Signaling, Metabolism, and Aging, Institute of Molecular Biology and Biochemistry, Medical University of Graz, 8036 Graz, Austria.

Sabrina Büttner (S)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria; Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, 114 19 Stockholm, Sweden.

Kai-Uwe Fröhlich (KU)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria.

Andrej Shevchenko (A)

Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

Tobias Eisenberg (T)

Institute of Molecular Biosciences, NAWI Graz, University of Graz, 8010 Graz, Austria; Central Lab Gracia, NAWI Graz, University of Graz, 8010 Graz, Austria; BioTechMed-Graz, 8010 Graz, Austria. Electronic address: tobias.eisenberg@uni-graz.at.

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Acétates › Acetyl-CoA carboxylase 1-dependent lipogenesis...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Enzymes multifonctionnelles › Acetyl-coA carboxylase › Acetyl-CoA carboxylase 1-dependent lipogenesis...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Acetyl-CoA carboxylase 1-dependent lipogenesis...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Lipogenèse › Acetyl-CoA carboxylase 1-dependent lipogenesis...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › Acetyl-CoA carboxylase 1-dependent lipogenesis...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Mutagenèse dirigée › Acetyl-CoA carboxylase 1-dependent lipogenesis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Acetyl-CoA carboxylase 1-dependent lipogenesis...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Acetyl-CoA carboxylase 1-dependent lipogenesis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Acetyl-CoA carboxylase 1-dependent lipogenesis...