Exploring the Application of the DSA-TOF, a Direct, High-resolution Time-of-Flight Mass Spectrometry Technique for the Screening of Potential Adulterated and Contaminated Herbal Medicines.
Adulteration
Contamination
Direct mass spectrometry
Herbal medicines
Pharmacovigilance
Journal
Journal of the American Society for Mass Spectrometry
ISSN: 1879-1123
Titre abrégé: J Am Soc Mass Spectrom
Pays: United States
ID NLM: 9010412
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
02
10
2018
accepted:
20
05
2019
revised:
15
04
2019
pubmed:
19
6
2019
medline:
21
1
2020
entrez:
19
6
2019
Statut:
ppublish
Résumé
Global consumption of complementary and alternative medicines, including herbal medicines, has increased substantially, and recent reports of adulteration demonstrate the need for high throughput and extensive pharmacovigilance to ensure product safety and quality. Three different standard reference materials and five previously analyzed herbal medicines have been used as a proof of concept for the application of adulteration/contamination screening using a Direct Sample Analysis (DSA) ion source with TOF MS on the Perkin Elmer AxION 2 TOF. This technique offers the advantages of minimum sample preparation, rapid analysis, and mass accuracies of 5 ppm. The DSA TOF analysis correlates well with the previous analysis on the initial sample set (which found undeclared herbal ingredients), with the added advantage of detecting previously untargeted compounds, including species-specific flavonoids and alkaloids. The rapid analysis using the DSA-TOF facilitates screening for hundreds of compounds in minutes with minimal sample preparation, generating a comprehensive profile for each sample. Graphical Abstract.
Identifiants
pubmed: 31209791
doi: 10.1007/s13361-019-02256-w
pii: 10.1007/s13361-019-02256-w
doi:
Substances chimiques
Capsules
0
Plant Preparations
0
Tablets
0
Tea
0
Vitamins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1713-1719Subventions
Organisme : National Health and Medical Research Council
ID : 1061329
Organisme : Australian Government Research Training Program
ID : N/A
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