DNA repair and cancer in colon and rectum: Novel players in genetic susceptibility.

Adult Aged Biological Variation, Population / genetics Carcinogenesis / genetics Case-Control Studies Colon / pathology Colonic Neoplasms / genetics DNA Modification Methylases / genetics DNA Repair / genetics DNA Repair Enzymes / genetics DNA-Binding Proteins / genetics Female Genetic Predisposition to Disease Humans Male Middle Aged MutL Protein Homolog 1 / genetics Polymorphism, Single Nucleotide Rectal Neoplasms / genetics Rectum / pathology Registries / statistics & numerical data Risk Assessment Tumor Suppressor Proteins / genetics Young Adult
DNA repair cancer susceptibility colon cancer genome-wide association studies rectal cancer single nucleotide polymorphisms

Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
15 01 2020
Historique:
received: 25 02 2019
accepted: 27 05 2019
pubmed: 19 6 2019
medline: 20 2 2020
entrez: 19 6 2019
Statut: ppublish

Résumé

Interindividual differences in DNA repair systems may play a role in modulating the individual risk of developing colorectal cancer. To better ascertain the role of DNA repair gene polymorphisms on colon and rectal cancer risk individually, we evaluated 15,419 single nucleotide polymorphisms (SNPs) within 185 DNA repair genes using GWAS data from the Colon Cancer Family Registry (CCFR) and the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), which included 8,178 colon cancer, 2,936 rectum cancer cases and 14,659 controls. Rs1800734 (in MLH1 gene) was associated with colon cancer risk (p-value = 3.5 × 10

Identifiants

DOI: 10.1002/ijc.32516 PMID: 31209889 PMC: PMC7301215
pubmed: 31209889
doi: 10.1002/ijc.32516
pmc: PMC7301215
mid: NIHMS1059427
doi:

Substances chimiques

DNA-Binding Proteins 0
MLH1 protein, human 0
RAD51B protein, human 0
Tumor Suppressor Proteins 0
DNA Modification Methylases EC 2.1.1.-
MGMT protein, human EC 2.1.1.63
MutL Protein Homolog 1 EC 3.6.1.3
DNA Repair Enzymes EC 6.5.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

363-372

Subventions

Organisme : NCI NIH HHS
ID : U01 CA074799
Pays : United States
Organisme : NCI NIH HHS
ID : K05 CA154337
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100046C
Pays : United States
Organisme : NIH HHS
ID : U01 CA167552
Pays : United States
Organisme : WHI NIH HHS
ID : HHSN268201100004C
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA148107
Pays : United States
Organisme : NIH HHS
ID : K05 CA154337
Pays : United States
Organisme : NIH HHS
ID : R01 CA60987
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA059045
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100001I
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA076366
Pays : United States
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Informations de copyright

© 2019 UICC.

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Auteurs

Barbara Pardini (B)

Italian Institute for Genomic Medicine (IIGM), Turin, Italy.
Department of Medical Sciences, University of Turin, Turin, Italy.
ORCID: 0000-0001-9571-4257

Alda Corrado (A)

Department of Biology, University of Pisa, Pisa, Italy.

Elisa Paolicchi (E)

Department of Biology, University of Pisa, Pisa, Italy.

Giovanni Cugliari (G)

Italian Institute for Genomic Medicine (IIGM), Turin, Italy.
Department of Medical Sciences, University of Turin, Turin, Italy.

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.

Stephane Bezieau (S)

Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU), Nantes, France.

Stephanie A Bien (SA)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
School of Public Health, University of Washington, Seattle, WA.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Bette J Caan (BJ)

Kaiser Permanente Medical Care Program of Northern California, Oakland, CA.

Peter T Campbell (PT)

Epidemiology Research Program, American Cancer Society, Atlanta, GA.

Graham Casey (G)

Public Health Sciences, University of Virginia, Charlottesville, VA.

Andrew T Chan (AT)

Division of Gastroenterology, Massachusetts General Hospital, Boston, MA.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Michelle Cotterchio (M)

Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada.

Manish Gala (M)

Division of Gastroenterology, Massachusetts General Hospital, Boston, MA.

Steven J Gallinger (SJ)

Department of Surgery, Mount Sinai Hospital, Toronto, ON, Canada.

Robert W Haile (RW)

Stanford University School of Medicine, Stanford, CA.

Tabitha A Harrison (TA)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Richard B Hayes (RB)

Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY.

Michael Hoffmeister (M)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-8307-3197

John L Hopper (JL)

Melbourne School of Population Health, The University of Melbourne, Melbourne, VIC, Australia.

Li Hsu (L)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Jeroen Huyghe (J)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Mark A Jenkins (MA)

Melbourne School of Population Health, The University of Melbourne, Melbourne, VIC, Australia.

Loic Le Marchand (L)

Epidemiology Program, Research Cancer Center of Hawaii, University of Hawaii, Honolulu, HI.

Yi Lin (Y)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Noralane M Lindor (NM)

Department of Health Sciences Research, Mayo Clinic Arizona, Scottsdale, AZ.

Hongmei Nan (H)

Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN.

Polly A Newcomb (PA)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Shuji Ogino (S)

Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA.
Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
Broad Institute of MIT and Harvard, Cambridge, MA.

John D Potter (JD)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Robert E Schoen (RE)

Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA.

Martha L Slattery (ML)

Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT.
ORCID: 0000-0002-1655-6543

Emily White (E)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Ludmila Vodickova (L)

Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
Department of Molecular Biology of Cancer, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic.

Veronika Vymetalkova (V)

Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
Department of Molecular Biology of Cancer, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic.

Pavel Vodicka (P)

Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
Department of Molecular Biology of Cancer, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic.

Federica Gemignani (F)

Department of Biology, University of Pisa, Pisa, Italy.

Ulrike Peters (U)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Alessio Naccarati (A)

Italian Institute for Genomic Medicine (IIGM), Turin, Italy.
Department of Molecular Biology of Cancer, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, Czech Republic.

Stefano Landi (S)

Department of Biology, University of Pisa, Pisa, Italy.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Phénomènes biologiques › Variation intra-population › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Côlon › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › DNA modification methylases › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Enzymes de réparation de l'ADN › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines MutL › Protéine-1 homologue de MutL › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Tumeurs du rectum › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Rectum › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enregistrements › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › DNA repair and cancer in colon and rectum:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › DNA repair and cancer in colon and rectum:...