Flavors of Flaviviral RNA Structure: towards an Integrated View of RNA Function from Translation through Encapsidation.
Dengue virus (DENV)
RNA-dependent RNA polymerase (RdRp)
flaviviruses
host-virus interactions
nonstructural protein 5 (NS5)
untranslated region (UTR)
viral RNA genome
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
07
01
2019
revised:
02
05
2019
pubmed:
19
6
2019
medline:
6
5
2020
entrez:
19
6
2019
Statut:
ppublish
Résumé
For many viruses, RNA is the holder of genetic information and serves as the template for both replication and translation. While host and viral proteins play important roles in viral decision-making, the extent to which viral RNA (vRNA) actively participates in translation and replication might be surprising. Here, the focus is on flaviviruses, which include common human scourges such as dengue, West Nile, and Zika viruses, from an RNA-centric viewpoint. In reviewing more recent findings, an attempt is made to fill knowledge gaps and revisit some canonical views of vRNA structures involved in replication. In particular, alternative views are offered on the nature of the flaviviral promoter and genome cyclization, and the feasibility of refining in vitro-derived models with modern RNA probing and sequencing methods is pointed out. By tracing vRNA structures from translation through encapsidation, a dynamic molecule closely involved in the self-regulation of viral replication is revealed.
Identifiants
pubmed: 31210384
doi: 10.1002/bies.201900003
pmc: PMC7161798
doi:
Substances chimiques
3' Untranslated Regions
0
5' Untranslated Regions
0
NS5 protein, flavivirus
0
RNA, Untranslated
0
RNA, Viral
0
Viral Nonstructural Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900003Informations de copyright
© 2019 WILEY Periodicals, Inc.
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