Genome Organization in and around the Nucleolus.
NoRC
Nucleolus
cancer
chromatin
embryonic stem cells
epigenetics
genome architecture
genome instability
lamina-associated domains(LADs)
lncRNA
nucleolus-associated domains (NADs)
rRNA genes
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
12 06 2019
12 06 2019
Historique:
received:
23
04
2019
revised:
09
06
2019
accepted:
11
06
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
20
6
2019
Statut:
epublish
Résumé
The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis takes place, and forms around the nucleolar organizer regions (NORs) that comprise ribosomal RNA (rRNA) genes. Each cell contains hundreds of rRNA genes, which are organized in three distinct chromatin and transcriptional states-silent, inactive and active. Increasing evidence indicates that the role of the nucleolus and rRNA genes goes beyond the control of ribosome biogenesis. Recent results highlighted the nucleolus as a compartment for the location and regulation of repressive genomic domains and, together with the nuclear lamina, represents the hub for the organization of the inactive heterochromatin. In this review, we aim to describe the crosstalk between the nucleolus and the rest of the genome and how distinct rRNA gene chromatin states affect nucleolus structure and are implicated in genome stability, genome architecture, and cell fate decision.
Identifiants
pubmed: 31212844
pii: cells8060579
doi: 10.3390/cells8060579
pmc: PMC6628108
pii:
doi:
Substances chimiques
RNA, Ribosomal
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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