Plasmacytoid dendritic cells develop from Ly6D
Animals
Antigens, Ly
/ metabolism
B-Lymphocytes
/ immunology
Biomarkers
Bone Marrow Cells
/ cytology
Cell Differentiation
/ genetics
Dendritic Cells
/ cytology
Flow Cytometry
GPI-Linked Proteins
/ metabolism
Gene Expression
Gene Expression Profiling
Lymphoid Progenitor Cells
/ cytology
Mice
Myeloid Progenitor Cells
/ cytology
Transcriptome
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
11
06
2018
accepted:
13
05
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
10
7
2019
Statut:
ppublish
Résumé
Dendritic cells (DC) are currently classified as conventional DCs (cDCs) and plasmacytoid DCs (pDCs). Through a combination of single-cell transcriptomic analysis, mass cytometry, in vivo fate mapping and in vitro clonal assays, here we show that, at the single-cell level, the priming of mouse hematopoietic progenitor cells toward the pDC lineage occurs at the common lymphoid progenitor stage, indicative of early divergence of the pDC and cDC lineages. We found the transcriptional signature of a pDC precursor stage, defined here, in the IL-7Rα
Identifiants
pubmed: 31213723
doi: 10.1038/s41590-019-0420-3
pii: 10.1038/s41590-019-0420-3
doi:
Substances chimiques
Antigens, Ly
0
Biomarkers
0
GPI-Linked Proteins
0
Ly6d protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
852-864Références
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