C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases.
Adolescent
Adult
Antibodies, Monoclonal
/ metabolism
Autoantibodies
/ metabolism
Complement C3
/ metabolism
Complement C3-C5 Convertases
/ metabolism
Complement C5
/ metabolism
Epitopes
/ metabolism
Female
Glomerulonephritis, Membranous
/ immunology
Humans
Immunoglobulin G
/ metabolism
Kidney
/ pathology
Male
Young Adult
C3 glomerulopathy
C3NeF
C5Nef
Eculizumab
complement
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
09
12
2018
accepted:
23
04
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
22
8
2020
Statut:
epublish
Résumé
C3 glomerulopathy (C3G) is a severe kidney disease, which is caused by defective regulation of the alternative complement pathway. Disease pathogenesis is heterogeneous and is caused by both autoimmune and genetic factors. Here we characterized IgG autoantibodies derived from 33 patients with autoimmune C3 glomerulopathy. Serum antibodies from all 33 patients as well as purified IgGs bound to the
Identifiants
pubmed: 31214159
doi: 10.3389/fimmu.2019.01030
pmc: PMC6554336
doi:
Substances chimiques
Antibodies, Monoclonal
0
Autoantibodies
0
Complement C3
0
Complement C5
0
Epitopes
0
Immunoglobulin G
0
Complement C3-C5 Convertases
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1030Références
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