Individual
Animals
Biomarkers
Cell Plasticity
/ genetics
Disease Models, Animal
Fluorescent Antibody Technique
Gene Expression Regulation
Immunophenotyping
In Situ Hybridization
Lectins
/ genetics
Mice
Microglia
/ immunology
Molecular Imaging
Nitric Oxide Synthase Type II
/ genetics
Stroke
/ genetics
beta-N-Acetylhexosaminidases
/ genetics
M1-like phenotype
M2-like phenotype
Ym1
bioluminescence imaging
iNOS
microglia
polarization phenotype
stroke
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
08
2018
accepted:
15
05
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
29
10
2020
Statut:
epublish
Résumé
Microglia are the brain-innate immune cells which actively surveil their environment and mediate multiple aspects of neuroinflammation, due to their ability to acquire diverse activation states and phenotypes. Simplified, M1-like microglia are defined as pro-inflammatory cells, while the alternative M2-like cells promote neuroprotection. The modulation of microglia polarization is an appealing neurotherapeutic strategy for stroke and other brain lesions, as well as neurodegenerative diseases. However, the activation profile and change of phenotype during experimental stroke is not well understood. With a combined magnetic resonance imaging (MRI) and optical imaging approach and genetic targeting of two key genes of the M1- and M2-like phenotypes, iNOS and Ym1, we were able to monitor
Identifiants
pubmed: 31214190
doi: 10.3389/fimmu.2019.01236
pmc: PMC6558167
doi:
Substances chimiques
Biomarkers
0
Lectins
0
NOS2 protein, human
EC 1.14.13.39
Nitric Oxide Synthase Type II
EC 1.14.13.39
Chil3 protein, mouse
EC 3.2.1.52
beta-N-Acetylhexosaminidases
EC 3.2.1.52
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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