Silencing cryptic specialized metabolism in
Anti-Bacterial Agents
/ biosynthesis
Bacterial Proteins
/ genetics
Binding Sites
Biosynthetic Pathways
/ genetics
Cell Nucleus
/ metabolism
Chromosomes, Bacterial
/ genetics
Gene Expression Regulation, Bacterial
Gene Transfer, Horizontal
/ genetics
Genes, Bacterial
Metabolome
/ genetics
Mutation
/ genetics
Phenotype
Streptomyces
/ genetics
Volatilization
DNA-binding protein
Streptomyces
antibiotics
infectious disease
microbiology
nucleoid-associated protein
repressor
specialized metabolism
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
19 06 2019
19 06 2019
Historique:
received:
14
04
2019
accepted:
04
06
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
26
2
2020
Statut:
epublish
Résumé
Lsr2 is a nucleoid-associated protein conserved throughout the actinobacteria, including the antibiotic-producing
Identifiants
pubmed: 31215866
doi: 10.7554/eLife.47691
pii: 47691
pmc: PMC6584129
doi:
pii:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Banques de données
GEO
['GSE115439']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019, Gehrke et al.
Déclaration de conflit d'intérêts
EG, XZ, SP, AJ, CR, SJ, H, SG, ST, SB, JH, EC, JN, ME No competing interests declared
Références
Bioinformatics. 2007 Nov 1;23(21):2947-8
pubmed: 17846036
Mol Microbiol. 1993 Oct;10(2):273-282
pubmed: 28776853
BMC Genomics. 2013 Aug 16;14:558
pubmed: 23947565
Mol Microbiol. 2015 Oct;98(2):357-69
pubmed: 26175201
Genome Biol. 2008;9(9):R137
pubmed: 18798982
Mol Microbiol. 2015 Dec;98(5):864-77
pubmed: 26268801
Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10907-11
pubmed: 1961761
Nat Prod Rep. 2011 Jul;28(7):1311-33
pubmed: 21611665
mBio. 2012 Dec 11;3(6):
pubmed: 23232715
Nat Rev Microbiol. 2007 Feb;5(2):157-61
pubmed: 17191074
Antimicrob Agents Chemother. 2014 Dec;58(12):7441-50
pubmed: 25267678
Genome Biol. 2009;10(3):R25
pubmed: 19261174
Nucleic Acids Res. 2013 Apr;41(7):4171-84
pubmed: 23427309
Anal Chem. 2006 Feb 1;78(3):779-87
pubmed: 16448051
mBio. 2019 Feb 5;10(1):
pubmed: 30723132
EMBO Rep. 2008 Jul;9(7):670-5
pubmed: 18511939
Elife. 2017 Jan 03;6:
pubmed: 28044982
Elife. 2017 Sep 26;6:
pubmed: 28949292
Angew Chem Int Ed Engl. 2011 Mar 21;50(13):2951-3
pubmed: 21404376
Proteomics. 2010 Jul;10(13):2486-97
pubmed: 20432484
Bioinformatics. 2010 Dec 15;26(24):3125-6
pubmed: 20956244
Nat Rev Microbiol. 2009 Jan;7(1):36-49
pubmed: 19079351
PLoS Genet. 2010 Nov 11;6(11):e1001207
pubmed: 21085634
Mol Microbiol. 2010 Jan;75(2):280-93
pubmed: 19968792
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1541-6
pubmed: 12563033
Science. 2005 Sep 30;309(5744):2216-9
pubmed: 16195462
Chem Sci. 2017 Apr 1;8(4):2823-2831
pubmed: 28553520
J Bacteriol. 2009 Nov;191(21):6489-500
pubmed: 19717607
Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1130-9
pubmed: 24616526
Genome Biol. 2015 Jan 13;16:1
pubmed: 25583448
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18947-52
pubmed: 19028873
ACS Chem Biol. 2017 Mar 17;12(3):628-634
pubmed: 28075554
J Bacteriol. 2007 Jul;189(14):5284-92
pubmed: 17513473
mBio. 2017 Jun 6;8(3):
pubmed: 28588130
Sci Rep. 2012;2:509
pubmed: 22798986
Nucleic Acids Res. 2018 Jun 20;46(11):5717-5725
pubmed: 29757411
Appl Microbiol Biotechnol. 2013 Jan;97(1):87-98
pubmed: 23143535
Mol Microbiol. 2013 Jan;87(1):30-48
pubmed: 23106203
J Bacteriol. 1999 Jan;181(1):204-11
pubmed: 9864331
Nucleic Acids Res. 2000 Sep 15;28(18):3504-10
pubmed: 10982869
J Bacteriol. 2009 Nov;191(21):6501-12
pubmed: 19717604
J Ind Microbiol Biotechnol. 2014 Feb;41(2):415-24
pubmed: 24326978
Genes Dev. 2010 Jul 1;24(13):1345-50
pubmed: 20595230
PLoS Pathog. 2006 Aug;2(8):e81
pubmed: 16933988
Nature. 2006 Nov 16;444(7117):387-90
pubmed: 17108966
Mol Microbiol. 1996 Mar;19(5):965-75
pubmed: 8830277
ACS Synth Biol. 2015 Jun 19;4(6):723-8
pubmed: 25458909
Nature. 2002 May 9;417(6885):141-7
pubmed: 12000953
Science. 2006 Jul 14;313(5784):236-8
pubmed: 16763111
Nat Rev Microbiol. 2019 Mar;17(3):167-180
pubmed: 30531948
Genes Dev. 2007 Jun 15;21(12):1456-71
pubmed: 17575047
BMC Biotechnol. 2019 Mar 20;19(1):18
pubmed: 30894153
Chembiochem. 2016 Nov 17;17(22):2189-2198
pubmed: 27605017
J Antibiot (Tokyo). 2013 Jul;66(7):387-400
pubmed: 23612726
Nat Biotechnol. 2013 Oct;31(10):922-7
pubmed: 24056948
Nat Biotechnol. 2011 Jan;29(1):24-6
pubmed: 21221095
J Antibiot (Tokyo). 2017 Jul;70(8):865-870
pubmed: 28442735
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5154-9
pubmed: 20133735
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
J Bacteriol. 2008 Nov;190(21):7052-9
pubmed: 18776007
Plasmid. 2014 Sep;75:1-11
pubmed: 24998344
Mol Microbiol. 2019 Apr;111(4):981-994
pubmed: 30633392
Genes Dev. 2014 Feb 1;28(3):214-9
pubmed: 24449106
Biotechnol Adv. 2019 Nov 1;37(6):107345
pubmed: 30738111
FEMS Microbiol Rev. 2014 May;38(3):345-79
pubmed: 24164321
Nat Prod Rep. 2007 Apr;24(2):358-92
pubmed: 17390001
Bioinformatics. 2011 Mar 15;27(6):863-4
pubmed: 21278185
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Nucleic Acids Res. 2017 Jul 3;45(W1):W36-W41
pubmed: 28460038
J Biotechnol. 2013 Jan 20;163(2):179-83
pubmed: 22820338
Nucleic Acids Res. 2003 Jul 15;31(14):e73
pubmed: 12853650
Adv Appl Microbiol. 2004;54:107-28
pubmed: 15251278
Nat Rev Microbiol. 2006 Dec;4(12):887-99
pubmed: 17109029
J Proteome Res. 2011 Dec 2;10(12):5481-92
pubmed: 21999169
Mol Microbiol. 2014 Aug;93(3):391-402
pubmed: 24964724
mBio. 2013 Sep 24;4(5):e00684-13
pubmed: 24065632
BMC Bioinformatics. 2010 Jul 23;11:395
pubmed: 20650010
Genes Dev. 2010 Feb 15;24(4):339-44
pubmed: 20159954
Gene. 1992 Feb 1;111(1):61-8
pubmed: 1547955
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W202-8
pubmed: 19458158
Curr Opin Microbiol. 2015 Feb;23:8-13
pubmed: 25461567
Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10690-5
pubmed: 21673140
Microbiol Mol Biol Rev. 2015 Nov 25;80(1):1-43
pubmed: 26609051
Microbiol Mol Biol Rev. 2013 Mar;77(1):112-43
pubmed: 23471619
Anal Biochem. 1987 Apr;162(1):156-9
pubmed: 2440339