Haploidentical vs haplo-cord transplant in adults under 60 years receiving fludarabine and melphalan conditioning.
Adult
Bone Marrow Transplantation
/ methods
Cord Blood Stem Cell Transplantation
/ adverse effects
Cyclophosphamide
/ administration & dosage
Disease-Free Survival
Enzyme Inhibitors
/ administration & dosage
Female
Graft vs Host Disease
/ drug therapy
Haplotypes
/ drug effects
Hematologic Neoplasms
/ mortality
Hematopoietic Stem Cell Transplantation
/ methods
Humans
Immunosuppressive Agents
/ administration & dosage
Male
Melphalan
/ administration & dosage
Middle Aged
Mycophenolic Acid
/ administration & dosage
Myeloablative Agonists
/ administration & dosage
Neutrophils
/ drug effects
Recovery of Function
/ drug effects
Retrospective Studies
Tacrolimus
/ administration & dosage
Transplantation Conditioning
/ methods
Transplantation, Homologous
/ statistics & numerical data
Vidarabine
/ administration & dosage
Whole-Body Irradiation
/ adverse effects
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
25 06 2019
25 06 2019
Historique:
received:
25
03
2019
accepted:
11
05
2019
entrez:
21
6
2019
pubmed:
21
6
2019
medline:
17
6
2020
Statut:
ppublish
Résumé
Haplo-identical transplant with posttransplant cyclophosphamide (haplo) and umbilical cord blood transplant supported by third-party CD34 cells (haplo-cord) are competing approaches to alternative donor transplant. We compared, in adults younger than age 60 years, the outcomes of 170 haplo at 1 institution with that of 137 haplo-cord at 2 other institutions. All received reduced intensity conditioning with fludarabine and melphalan ± total body irradiation. GVHD prophylaxis for haplo consisted of cyclophosphamide, tacrolimus, and mycophenolate, whereas haplo-cord received antithymocyte globulin, tacrolimus, and mycophenolate. Haplo transplant used mostly bone marrow, and peripheral blood stem cells were used in haplo-cord transplants. Haplo-cord were older and had more advanced disease. Haplo-cord hastened median time to neutrophil (11 vs 18 days,
Identifiants
pubmed: 31217161
pii: bloodadvances.2019000200
doi: 10.1182/bloodadvances.2019000200
pmc: PMC6595267
doi:
Substances chimiques
Enzyme Inhibitors
0
Immunosuppressive Agents
0
Myeloablative Agonists
0
Cyclophosphamide
8N3DW7272P
Vidarabine
FA2DM6879K
Mycophenolic Acid
HU9DX48N0T
fludarabine
P2K93U8740
Melphalan
Q41OR9510P
Tacrolimus
WM0HAQ4WNM
Banques de données
ClinicalTrials.gov
['NCT01810588', 'NCT01050946']
Types de publication
Clinical Trial
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1858-1867Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Informations de copyright
© 2019 by The American Society of Hematology.
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