Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish.


Journal

Disease models & mechanisms
ISSN: 1754-8411
Titre abrégé: Dis Model Mech
Pays: England
ID NLM: 101483332

Informations de publication

Date de publication:
16 07 2019
Historique:
received: 03 03 2019
accepted: 13 06 2019
pubmed: 22 6 2019
medline: 6 5 2020
entrez: 22 6 2019
Statut: epublish

Résumé

The aberrant activation of developmental processes triggers diverse cancer types. Chordoma is a rare, aggressive tumor arising from transformed notochord remnants. Several potentially oncogenic factors have been found to be deregulated in chordoma, yet causation remains uncertain. In particular, sustained expression of

Identifiants

pubmed: 31221659
pii: dmm.039545
doi: 10.1242/dmm.039545
pmc: PMC6679381
pii:
doi:

Substances chimiques

Fetal Proteins 0
T-Box Domain Proteins 0
Receptor Protein-Tyrosine Kinases EC 2.7.10.1
Brachyury protein EQ43SC3GDB

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States

Informations de copyright

© 2019. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

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Auteurs

Gianluca D'Agati (G)

Institute of Molecular Life Sciences, University of Zürich, 8057 Zürich, Switzerland.

Elena María Cabello (EM)

Institute of Molecular Life Sciences, University of Zürich, 8057 Zürich, Switzerland.

Karl Frontzek (K)

Institute of Neuropathology, University Hospital Zürich, 8091 Zürich, Switzerland.

Elisabeth J Rushing (EJ)

Institute of Neuropathology, University Hospital Zürich, 8091 Zürich, Switzerland.

Robin Klemm (R)

Institute of Molecular Life Sciences, University of Zürich, 8057 Zürich, Switzerland.

Mark D Robinson (MD)

Institute of Molecular Life Sciences, University of Zürich, 8057 Zürich, Switzerland.
SIB Swiss Institute of Bioinformatics, University of Zürich, 8057 Zürich, Switzerland.

Richard M White (RM)

Cancer Biology & Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Christian Mosimann (C)

Institute of Molecular Life Sciences, University of Zürich, 8057 Zürich, Switzerland.

Alexa Burger (A)

Institute of Molecular Life Sciences, University of Zürich, 8057 Zürich, Switzerland alexa.burger@imls.uzh.ch.

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